本文選題：尿微量蛋白 + 血管性癡呆�。� 參考：《吉林大學》2015年碩士論文

【摘要】：目的： 目前，對于血管性癡呆危險因素及其發(fā)病機制的研究很多，但是明確的機制尚不十分清楚，大多數(shù)研究都是從腦血管病方面進行闡述的。然而，近些年對尿微量蛋白的研究發(fā)現(xiàn)，其與公認的血管性癡呆病因涉及的腦血管病及其危險因素密切相關(guān)。故本文通過尿微量蛋白(microalbuminuria MA）與血管性癡呆（Vascular Dementia，VD）的相關(guān)性研究，探討VD的可能危險因素,對尋求其有效的預防和治療措施或許具有十分重要的意義。 實驗方法： 先對36例血管性癡呆患者，38例腦梗塞（Cerebral Infarction,CI）患者，32例正常健康者(Normal Control,NC)進行病例對照分析，再將VD組中的27例多梗死性癡呆（multi-infarct dementia，MID）患者，同CI組及NC組患者進行病例對照分析。運用免疫比濁法檢測患者MA值，分析MA與VD的相關(guān)性，并對各組觀察對象一般臨床資料進行分析比較，尋找VD的危險因素。 實驗結(jié)果： 1、在VD組、CI組、NC組三組之間及MID組、CI組、NC組三組之間比較中，性別、年齡、文化程度、高脂血癥病史、吸煙史、飲酒史均無顯著差異(P0.05)；VD組、CI組、NC組三組及MID組、CI組、NC組三組在MMSE得分上均具有統(tǒng)計學意義(P0.05)；高血壓病史、高血脂病史、吸煙史、飲酒史在VD組、CI組、NC組三組及MID組、CI組、NC組三組對比中，均無顯著差異(P0.05)。 2、VD組、CI組、NC組三組MA值相比中（先測定尿白蛋白，排除尿白蛋白陽性者），VD組最高，NC組最低，進行統(tǒng)計學分析，VD組與CI組無顯著差異(P0.05)，VD組及CI組分別與NC組對比，均具有顯著差異(P0.05)，在MID組、CI組、NC組三組MA值相比，MID組最高，NC組最低，進行統(tǒng)計學分析，MID組MA值明顯高于其他兩組，并具有顯著性差異(P0.05)。 實驗結(jié)論： 1.VD患者（包括MID及其他類型VD）MA值稍高于CI患者，，兩者比較無統(tǒng)計學意義(P0.05)，VD患者MA值明顯高于健康對照者，兩者比較有統(tǒng)計學意義(P0.05)，CI患者MA值明顯高于健康對照者，兩者比較有統(tǒng)計學意義(P0.05)。 2.MID患者MA值明顯高于CI患者及健康對照者，且三者比較具有統(tǒng)計學意義(P0.05)，提示MA可能為MID的獨立危險因素。
[Abstract]:Objective: At present, there are many studies on the risk factors and pathogenesis of vascular dementia, but the clear mechanism is not very clear, most of the research is from the aspect of cerebrovascular disease. However, recent studies on urinary microproteins have found that they are closely associated with cerebrovascular disease and its risk factors, which are recognized as the etiology of vascular dementia. Therefore, by studying the correlation between microalbuminuria MAand vascular dementia and vascular dementia, the possible risk factors of VD may be of great significance in seeking effective preventive and therapeutic measures. Experimental methods: Thirty-eight patients with cerebral infarction (Cerebral InfarctionCII) and 32 normal controls (normal control NCC) were analyzed in 36 patients with vascular dementia and 27 patients with multi-infractive dementia (MDD) in VD group, same as CI group and NC group. The correlation between MA and VD was analyzed by using immune turbidimetric method, and the general clinical data of each group were analyzed and compared to find out the risk factors of VD. Experimental results: 1. Sex, age, education, history of hyperlipidemia and smoking were compared between the three groups of VD group and MID group. There was no significant difference in the history of alcohol consumption. There was no significant difference in the MMSE scores among the three groups (P 0.05, P 0.05), the history of hypertension, hyperlipidemia and smoking. There was no significant difference in the history of alcohol consumption among the three groups of VD group and MID group, and there was no significant difference between the three groups (P 0.05). (2) the MA values of the three groups in CI group were higher than those in NC group (the urine albumin was measured first, and the highest and lowest group was excluded from the positive group. There was no significant difference between the VD group and the CI group, P0.05D group and CI group were compared with the NC group respectively), there was no significant difference between the VD group and the CI group, and the difference was significant between the VD group and the CI group. There was significant difference (P 0.05) between the three groups in MID group and CI group. The MA value of Mid group was significantly higher than that of the other two groups, and there was a significant difference in MA value of Mid group compared with that of Mid group (P 0.05). The experimental conclusions are as follows: The MA value of 1.VD patients (including MID and other types of VD)MA) was slightly higher than that of CI patients. There was no significant difference between the two groups. The MA values of 1.VD patients were significantly higher than those of healthy controls, and the MA values of patients with 1.VD and other types of VD)MA were significantly higher than those of healthy controls. There was significant difference between the two groups (P 0.05). The MA value in 2.MID patients was significantly higher than that in CI patients and healthy controls, and there was statistical significance among the three groups, suggesting that MA might be an independent risk factor for MID.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R749.13

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