本文選題：腎素-血管緊張素-醛固酮系統(tǒng) + 腦缺血　； 參考：《中國老年學(xué)雜志》2017年14期

【摘要】：目的觀察血管性癡呆(VD)大鼠血漿和腦組織腎素-血管緊張素(Ang)-醛固酮(ALD)系統(tǒng)(RAAS)的動態(tài)變化。方法經(jīng)水迷宮篩選出學(xué)習(xí)記憶能力正常雄性SD大鼠80只隨機分入正常組、模型組(1 d)、模型組(3 d)、模型組(7 d)、模型組(14 d)、模型組(21 d)、模型組(30 d),按照設(shè)計時間梯度采用不同時點分別結(jié)扎左、右雙側(cè)頸總動脈法制備VD模型大鼠。觀察正常組和模型組(30 d)的空間學(xué)習(xí)記憶情況,檢測血漿、腦皮質(zhì)及海馬腎素活性、AngⅡ、ALD水平以及腦組織病理學(xué)檢查。結(jié)果模型組(30 d)和正常組水迷宮數(shù)據(jù)比較差異顯著(P0.05),說明模型制備成功。血漿、皮質(zhì)及海馬中腎素活性、AngⅡ及ALD的水平模型組隨時間增加其水平總體呈現(xiàn)增高趨勢,但腦組織與血漿水平變化無線性相關(guān)性;腦組織光鏡下病理學(xué)觀察發(fā)現(xiàn),隨缺血時間增加腦皮質(zhì)及海馬損傷有加重趨勢。結(jié)論 RAAS在腦缺血的發(fā)生發(fā)展中有著重要作用。
[Abstract]:Objective to observe the dynamic changes of plasma and brain tissue renin-angiotensin angiotensin-aldosterone (ALD) system in rats with vascular dementia (VD). Methods 80 male Sprague-Dawley rats with normal learning and memory abilities were randomly divided into normal group by water maze. The VD model rats were established by ligating left and right common carotid arteries at different time points according to the design time gradient in model group, and model group, respectively, for 1 d, 3 d, 7 d, 14 d, 21 d, and 30 d respectively, according to the design time gradient, the left and right common carotid arteries were ligated at different time points. The spatial learning and memory were observed in normal group and model group at 30 days. The levels of Ang 鈪，

本文編號：1938129