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  本文選題：急性冠脈綜合征　切入點：PCI　出處：《青島大學》2014年碩士論文

【摘要】：目的：觀察左洛復對急性冠脈綜合征(ACS)PCI術后合并抑郁患者抗抑郁治療的療效及對其低密度脂蛋白(LDL)、高敏C反應蛋白(hsCRP)的影響。 方法：對150例確診為急性冠脈綜合征的患者行PCI術治療,術后從中篩選出伴有抑郁癥患者并通過漢密爾頓(HAMD)抑郁量表對其進行評分。后將合并有抑郁的患者隨機分成兩組,分別給予心理治療(對照組)和左洛復治療(治療組)。2月后對比兩組患者的LDL、hsCRP水平,再次利用HAMD抑郁量表進行評分,根據評分減分率判斷左洛復抗抑郁治療的療效。 結果： (1)2月后治療組LDL.hsCRP水平(分別為1.70±0.56mmol/L、0.27±0.02ng/ml)明顯低于對照組LDL、hsCRP水平(分別為2.13±0.62mmol/L、0.45±0.33ng/ml),差異具有統(tǒng)計學意義(P均0.05)。 (2)經治療后,兩組患者的抑郁癥狀均得到了改善,與對照組相比,治療組抗抑郁治療的效果要明顯優(yōu)于對照組(治愈及顯效的例數明顯多于對照組),差異具統(tǒng)計學意義(P0.05)。 (3)左洛復引起的藥物不良反應與對照組相比無明顯增加,兩組間差異無統(tǒng)計學意義(P0.1)。 結論： (1)對急性冠脈綜合征PCI術后合并有抑郁的患者給予左洛復治療是安全的。 (2)對抑郁的治療,藥物可能比單純給予心理治療更有效。 (3)左洛復通過對抑郁的治療,間接降低冠心病危險因子LDL、hsCRP的水平,對患者預后可能有重要意義。
[Abstract]:Aim: to observe the effect of zolofur on antidepressant treatment of patients with depression after acute coronary syndrome (ACSC) PCI and its effect on low density lipoprotein (LDL) and Gao Min C-reactive protein (Gao Min C reactive protein hsCRP).Methods: 150 patients with acute coronary syndrome were treated with PCI.The patients with depression were randomly divided into two groups. They were treated with psychotherapy (control group) and Zolofu (treatment group). Two months after treatment, the patients in both groups were compared with the level of HAMD hs CRP, and the scores were evaluated by HAMD depression scale.The efficacy of levofloxacin in antidepressant treatment was evaluated according to the score reduction rate.Results:After 2 months, the level of LDL.hsCRP in the treatment group (1.70 鹵0.56 mmol / L 0.27 鹵0.02 ng / ml, respectively) was significantly lower than that in the control group (2.13 鹵0.62 mmol / L 0.45 鹵0.33 ng / ml, P < 0.05).2) after treatment, the depressive symptoms of the two groups were improved. Compared with the control group, the effect of antidepressant treatment in the treatment group was obviously better than that in the control group (the number of cured and effective cases was obviously more than that in the control group, the difference was statistically significant (P 0.05).3) there was no significant increase in adverse drug reactions induced by zolofur compared with the control group, and there was no significant difference between the two groups (P 0.1).Conclusion:It is safe to treat acute coronary syndrome patients with depression after PCI.Drugs may be more effective than psychotherapy alone in the treatment of depression.Through the treatment of depression, Zolofu can indirectly reduce the level of LDL- hsCRP, which may play an important role in the prognosis of patients with coronary heart disease.
【學位授予單位】：青島大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R541.4;R749.4

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