本文選題：海洛因依賴　切入點：強制戒斷　出處：《中國醫(yī)學(xué)影像技術(shù)》2017年04期 　論文類型：期刊論文

【摘要】：目的探討不同戒斷時間對海洛因成癮者大腦靜息態(tài)下功能網(wǎng)絡(luò)的影響。方法 16名強制戒斷11~13個月的海洛因成癮者(PA12組)、20名強制戒斷5~7個月的海洛因成癮者(PA6組)納入靜息態(tài)fMRI研究。運用圖論理論構(gòu)建小世界腦網(wǎng)絡(luò),比較兩組海洛因成癮者小世界特性及核心節(jié)點特性,分析核心節(jié)點與戒斷時間的相關(guān)性。結(jié)果兩組腦網(wǎng)絡(luò)均具有小世界特性(γ≈1、λ?1)且差異無統(tǒng)計學(xué)意義(P0.05);PA12組較PA6組腦網(wǎng)絡(luò)的左側(cè)中央前回及左側(cè)海馬旁回節(jié)點介數(shù)值降低,左側(cè)楔葉、左側(cè)顳極及右側(cè)枕中回節(jié)點介數(shù)值升高(P均0.05)。左側(cè)中央前回(r=—0.52,P=0.001)、左側(cè)海馬旁回(r=—0.49,P=0.002)節(jié)點介數(shù)值均與戒斷時間呈負(fù)相關(guān),右側(cè)枕中回節(jié)點介數(shù)值與戒斷時間呈正相關(guān)(r=0.49,P=0.003)。結(jié)論戒斷5~7個月后,海洛因成癮者大腦網(wǎng)絡(luò)小世界拓?fù)浣Y(jié)構(gòu)趨于穩(wěn)定;長期戒斷有助于降低成癮者對毒品的相關(guān)記憶和潛在覓藥行為,恢復(fù)視覺空間注意能力。
[Abstract]:Objective to investigate the effect of different abstinence time on the functional network in the resting state of brain of heroin addicts. Methods 16 heroin addicts with 11 ~ 13 months of compulsory withdrawal and 20 heroin addicts with 5 ~ 7 months of compulsory withdrawal were randomly divided into two groups: group A (n = 16) and group A (n = 20). Into the study of resting fMRI. Using graph theory to construct a small world brain network, The characteristics of small world and core node of heroin addicts were compared, and the correlation between core nodes and withdrawal time was analyzed. Results the two groups of brain networks had small world characteristics (緯 鈮，

本文編號：1633630