發(fā)布時(shí)間：2018-03-12 21:22

  本文選題：糖尿病　切入點(diǎn)：型　出處：《中國(guó)糖尿病雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的調(diào)查T(mén)1DM兒童合并抑郁的患病現(xiàn)狀并分析其危險(xiǎn)因素。方法選取T1DM患兒225例,根據(jù)Beck抑郁自評(píng)量表(BDI)評(píng)分為T(mén)1DM合并抑郁組(T1DM+抑郁,BDI10)123例;單純T1DM組(T1DM,BDI≤10)102例。另根據(jù)BDI水平將T1DM+抑郁組分為輕度抑郁亞組(10BDI≤15)42例、中度抑郁亞組(16≤BDI25)40例及重度抑郁亞組(BDI≥25)41例。收集各組的臨床資料,采用多元逐步回歸和Logistic回歸分析BDI評(píng)分水平及T1DM患兒合并抑郁的影響因素。結(jié)果(1)T1DM+抑郁組糖尿病病程[(5.89±1.52)vs(4.13±1.44)年]、FPG[(8.22±1.50)vs(7.37±1.23)rnmol/L]、HbA_1c[(9.55±0.94)%vs(7.57±0.58)%]、胰島素用量[(61.75±13.54)vs(47.50±10.31)U]、DKA發(fā)生率[88(71.54%)vs 50(49.02%)]、低血糖發(fā)生率[48(39.02%)vs 19(18.63%)]及胰島素注射2次/d比例[60(48.78%)vs 26(25.49%)]均高于T1DM組,胰島素注射≤2次/d比例[27(21.95%)vs 51(50.00%)]低于T1DM組(P0.05或P0.01);(2)重度抑郁亞組年齡[(15.71±2.00)vs(12.18±2.32)vs(8.41±1.66)歲]、BMI[(19.44±2.18)vs(17.13±2.59)vs(17.52±2.41)kg/m~2]、FPG[(8.22±1.50)vs(7.37±1.23)vs(6.01±0.86)mmol/L]、HbA_1c[(10.58±1.34)%vs(9.05±1.23)%vs(8.42±1.41)%]、胰島素用量[(65.43±15.68)vs(57.72±13.63)vs(50.69±12.44)U]及胰島素注射2次/d比例[28(56.00%)vs15(30.00%)vs 7(14.00%)]均高于中度和輕度抑郁亞組,糖尿病病程[(3.22±1.01)vs(4.29±1.38)vs(5.74±1.35)年]低于中度和輕度抑郁亞組胰島素注射≤2次/d比例[5(21.74%)vs 7(30.43%)vs 11(47.83%)]低于輕度抑郁亞組(P0.05或P0。01);(3)多元逐步回歸分析發(fā)現(xiàn),年齡、糖尿病病程、FPG、HbA。c、DKA發(fā)生率、低血糖發(fā)生率、胰島素用量及胰島素注射2次/d是BDI評(píng)分的影響因素(P0.05)。Logistic回歸分析表明,女性患兒、糖尿病病程長(zhǎng)、胰島素注射2次/d、HbA_1c、DKA發(fā)生率和低血糖發(fā)生率高是T1DM兒童合并抑郁的危險(xiǎn)因素(P0.05)。結(jié)論T1DM患兒合并抑郁的發(fā)生率較高,應(yīng)及早篩查,及時(shí)干預(yù)。對(duì)于合并危險(xiǎn)因素的患兒,應(yīng)給予更多的心理關(guān)懷,預(yù)防抑郁的發(fā)生。
[Abstract]:Objective to investigate the prevalence of depression in children with T1DM and analyze its risk factors. According to the level of BDI, T1DM depression group was divided into mild depression group (n = 42), moderate depression subgroup (n = 16) and severe depression subgroup (n = 41). Multiple stepwise regression and Logistic regression analysis were used to analyze the BDI score and the influencing factors of depression in children with T1DM. Results the course of diabetes in T1DM depression group [5.89 鹵1.52 vs 4.13 鹵1.44) years] FPG [8.22 鹵1.50 vs 7.37 鹵1.23rnmol / L] HbA1c [9.55 鹵0.94VSD 7.57 鹵0.58%], insulin dosage [61.75 鹵13.54vs47.50 鹵10.31U] DKA [8871.54V vs 5049.02a vs 5049.02a], and the incidence of hypoglycemia were as follows. The ratio of two times / d injection [60% 48.78% vs 260.49%] was higher than that of T1DM group. The proportion of insulin injection 鈮，

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