本文選題：輕度認知功能障礙　切入點：時辰　出處：《山東中醫(yī)藥大學》2013年碩士論文　論文類型：學位論文

【摘要】：目的：了解不同時辰輕度認知功能障礙患者腦電圖的變化，提煉出客觀可量化的異常指標，探索輕度認知功能障礙患者腦電圖及MMSE量表的相關性，為日后早期診斷預防認知功能障礙提供依據(jù)。方法：以我院收治的輕度認知功能障礙老年患者30例為研究對象，并以社會招募正常健康老年人30例為對照，，分別進行MMSE測試和24小時腦電圖監(jiān)測。選取無干擾定標腦電圖以及子時、寅時、辰時、午時和申時、酉時六個不同時辰的腦電圖，比較兩組不同時辰腦電圖各波功率并對輕度認知功能障礙患者MMSE各項評分與腦電圖相關性分析。結果：1.無干擾定標腦電圖病例組和對照組的雙側(cè)頂枕α功率及大腦各位點的慢波功率差別有統(tǒng)計學意義（p㩳0.05）。2.寅時病例組與對照組α功率之間的比較有統(tǒng)計學意義（p㩳0.05），慢波功率比較無統(tǒng)計學意義（p＞0.05）。3.病例組及對照組在睡眠2期紡錘波的時限、頻率及密度差別有統(tǒng)計學意義（p㩳0.05）。4.辰時、午時、申時及酉時病例組和對照組的雙側(cè)頂枕α功率差別有統(tǒng)計學意義（p㩳0.05）；大腦各位點的慢波功率差別有統(tǒng)計學意義（p㩳0.05）。5.病例組辰時、午時、申時及酉時間α功率差別無統(tǒng)計學意義（p＞0.05）。6.病例組的MMSE中時間定向力、記憶力與腦電圖的慢波或α波存在相關性（p㩳0.05）。結論：1.不同時辰的α波功率、θ和δ波功率及子時睡眠2期紡錘波的密度、時限及頻率可以作為診斷輕度認知功能障礙的參考指標；2.寅時α波功率下降可以提示早期認知功能減退；3.清醒期辰時、午時、申時及酉時的不同時辰間輕度認知功能障礙的腦電圖差異參考意義不大；4.輕度認知功能障礙的MMSE時間定向力及記憶力與腦電圖α波、θ和δ波的絕對功率有相關性。
[Abstract]:Objective: to investigate the changes of electroencephalogram (EEG) in patients with mild cognitive impairment (MCI) at different times, to extract the objective and quantifiable abnormal indexes, and to explore the correlation between EEG and MMSE scale in patients with mild cognitive impairment. Methods: 30 elderly patients with mild cognitive impairment were selected as the study objects, and 30 normal and healthy elderly people were recruited as control. MMSE test and 24 hour EEG monitoring were carried out respectively. The EEG of six different times were selected, including non-interference calibrated EEG and sub-time, Yin, Chen, noon and Shen, and unitary time. The correlation between MMSE scores and EEG in patients with mild cognitive impairment was analyzed. Results: 1. A power of bilateral parietal occipital 偽 and large occipital power in non-interference calibrated EEG group and control group were compared. The difference of slow wave power in each point of the brain is statistically significant. The comparison of 偽 power between the case group and the control group was statistically significant. There was no significant difference in slow wave power between the two groups (P > 0.05). The time limit, frequency and density of spindles in the case group and the control group were significantly different in sleep phase 2. The difference of bilateral parietal occipital 偽 power between the case group and the control group was statistically significant. The difference of slow wave power in each point of the brain is statistically significant. There was no significant difference in 偽 power between the two groups (P > 0.05). Time orientation, memory and slow or 偽 wave of electroencephalogram were correlated with the time orientation in the case group (P > 0.05), and the correlation between the memory and the slow or 偽 wave of EEG was also found in the case group (P > 0.05). Conclusion: 1. 偽 wave power, 胃 and 未 wave power at different times, and density of spindles at sub-sleep stage 2, The time limit and frequency can be used as a reference index for the diagnosis of mild cognitive dysfunction. The decrease of alpha wave power can indicate early cognitive dysfunction. (4) the MMSE time orientation and memory of mild cognitive impairment were correlated with the absolute power of 偽 wave, 胃 wave and 未 wave of EEG.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R749.16

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