【摘要】：目的研究血清可溶性髓樣細(xì)胞觸發(fā)受體-1(s TREM-1)濃度檢測(cè)對(duì)重癥膿毒癥患者預(yù)后的判斷價(jià)值。方法回顧性分析重癥膿毒癥患者共83例,根據(jù)28 d死亡結(jié)局分為存活組(n=63)和死亡組(n=20),比較2組患者在基本情況、入院24 h APACHEⅡ評(píng)分最高值、全血C反應(yīng)蛋白(C-reactive protein,CRP)和乳酸(lactate,Lac)濃度、血清降鈣素(procalcitonin,PCT)和s TREM-1濃度等方面的差異,并繪制ROC曲線分析相關(guān)指標(biāo)對(duì)疾病的預(yù)后判斷及診斷價(jià)值,多因素Logistic回歸分析探討與疾病死亡相關(guān)的危險(xiǎn)因素。結(jié)果 2組患者基本情況差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。死亡組患者在APACHEⅡ評(píng)分最高值和血清s TREM-1濃度上要高于存活組(P0.05),而在血清PCT、全血CRP和Lac濃度上2組間比較,則差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。ROC曲線分析結(jié)果表明,血清s TREM-1濃度對(duì)重癥膿毒癥患者死亡預(yù)測(cè)的曲線下面積為0.77。多因素Logistic回歸分析結(jié)果顯示,APACHEⅡ評(píng)分和血清s TREM-1濃度是重癥膿毒癥患者死亡的獨(dú)立高危因素。結(jié)論血清s TREM-1濃度有望成為預(yù)測(cè)重癥膿毒癥患者預(yù)后的可靠指標(biāo),也可能是重癥膿毒癥患者死亡的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to study the prognostic value of serum soluble myeloid cell trigger receptor-1 (s TREM-1) in patients with severe sepsis. Methods Eighty-three patients with severe sepsis were retrospectively analyzed. According to the death outcome of 28 days, the patients were divided into two groups: survival group (n = 63) and death group (n = 20). The two groups were compared in the basic condition and the highest APACHE 鈪，

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