本文選題：重癥肌無(wú)力　切入點(diǎn)：胸腺切除　出處：《臨床神經(jīng)病學(xué)雜志》2017年01期

【摘要】：目的探討重癥肌無(wú)力(MG)患者胸腺切除術(shù)圍手術(shù)期并發(fā)肌無(wú)力危象的危險(xiǎn)因素。方法收集63例MG患者的臨床資料,按照圍手術(shù)期是否發(fā)生肌無(wú)力危象,分為發(fā)生危象組和未發(fā)生危象組,分析肌無(wú)力危象的危險(xiǎn)因素。結(jié)果本組發(fā)生肌無(wú)力危象12例(19.0%)(發(fā)生危象組),未發(fā)生肌無(wú)力危象51例(81.0%)(未發(fā)生危象組)。與發(fā)生危象組比較,未發(fā)生危象組Osserman分型、術(shù)式、手術(shù)時(shí)間、術(shù)中出血量及病理類(lèi)型差異有統(tǒng)計(jì)學(xué)意義(P0.05~0.01)。多變量Logistic回歸分析顯示,Osserman分型(Ⅱb+Ⅲ型)、手術(shù)時(shí)間(3 h)、術(shù)中出血量(100 ml)以及病理類(lèi)型(侵襲性胸腺瘤)是肌無(wú)力危象的獨(dú)立危險(xiǎn)因素(OR=55.257,95%CI:7.953~383.909,P=0.000;OR=105.243,95%CI:8.570~1292.357,P=0.000;OR=14.008,95%CI:2.597~75.559,P=0.002;OR=18.552,95%CI:4.368~78.789,P=0.000)。結(jié)論 Osserman分型Ⅱb+Ⅲ型、手術(shù)時(shí)間3 h、術(shù)中出血量100 ml以及侵襲性胸腺瘤是胸腺切除術(shù)圍手術(shù)期并發(fā)肌無(wú)力危象的獨(dú)立危險(xiǎn)因素。充分的術(shù)前評(píng)估準(zhǔn)備、減少術(shù)中出血及縮短手術(shù)時(shí)間有助減少肌無(wú)力危象發(fā)生。
[Abstract]:Objective to investigate the risk factors of perioperative myasthenia crisis in patients with myasthenia gravis (MG). Methods the clinical data of 63 patients with MG were collected. The risk factors of myasthenia crisis were analyzed. Results there were 12 cases of myasthenia crisis in this group, 51 cases had no myasthenia crisis group and 51 cases had no myasthenia crisis group. In the group without crisis, Osserman classification, operation method, operation time, The results of multivariate Logistic regression analysis showed that Osserman type (鈪，

本文編號(hào)：1662929