【摘要】：病理組織切片的預處理過程,包括組織樣本的選取、固定、脫水、透明、封蠟和包埋等多個流程,病理組織處理的質(zhì)量及處理速度,直接影響患者的診治,是醫(yī)學分析中非常重要的一個步驟。研究快速、自動化病理組織處理系統(tǒng),是具有重要醫(yī)學價值的研究課題。病理組織處理系統(tǒng)涉及機械設(shè)計與工藝制造、生物病理學科、傳感器技術(shù)、嵌入式系統(tǒng)等多門學科,是一個涉及多門學科的綜合性課題。最終目的,是制作一臺處理速度快,全自動的病理組織處理設(shè)備,有效提高病理組織處理的質(zhì)量,縮短病理處理時間。通過對病理組織處理過程的分析,構(gòu)建了一主多從的病理組織處理系統(tǒng)架構(gòu)。本文詳細介紹了病理組織處理系統(tǒng)從機部分的電路設(shè)計、程序?qū)崿F(xiàn),并介紹了病理組織處理系統(tǒng)中的一些關(guān)鍵技術(shù)。本文主要分為以下幾個部分:第一,緒論部分介紹了病理組織系統(tǒng)的課題來源及研究意義,總結(jié)了當前國內(nèi)外病理組織處理系統(tǒng)的現(xiàn)狀,汲取現(xiàn)有設(shè)備的優(yōu)點,并希望在設(shè)計的系統(tǒng)中對優(yōu)點進行發(fā)揚,對現(xiàn)有設(shè)備的缺點進行改進。第二,介紹了病理組織處理的概念,以及病理組織處理的工作流程。分析了病理組織處理系統(tǒng)的主要機械結(jié)構(gòu),對電氣系統(tǒng)進行了整體規(guī)劃。第三,使用超聲振蕩方法,加快病理處理過程。設(shè)計了超聲驅(qū)動電路,并一步步解決設(shè)計驅(qū)動電路過程中碰到的問題,最終拿出最優(yōu)的驅(qū)動解決方案。給出了超聲驅(qū)動的軟件實現(xiàn)思路。第四,為病理組織處理系統(tǒng)中的一些開關(guān)型負載設(shè)計了驅(qū)動電路,并設(shè)計出特定功能模塊的工作流程。以給出硬件驅(qū)動程序的方式,將各路開關(guān)型負載屏蔽起來,后續(xù)開發(fā)者只需按照接口要求,就可以直接控制相應(yīng)的開關(guān)型負載,不需要再進行驅(qū)動配置等繁瑣工作,并附出了驅(qū)動程序的源碼。第五,對所做工作進行一一驗證,驗證電路設(shè)計的正確性,驗證系統(tǒng)移植、協(xié)議的正確性,對編寫的程序代碼的結(jié)果進行驗證。項目組成員參與整體病理組織處理系統(tǒng)的聯(lián)合調(diào)試,包括通訊的測試,及系統(tǒng)長時間運行的穩(wěn)定性測試。第六,對所做項目作出總結(jié),并提出項目中需要改進的地方。
[Abstract]:The preprocessing process of pathological tissue sections, including the selection of tissue samples, fixation, dehydration, transparency, wax sealing and embedding, and the quality and speed of pathological tissue treatment directly affect the diagnosis and treatment of patients. Is a very important step in medical analysis. The research of rapid and automatic pathological tissue management system is an important subject of medical value. Pathological tissue processing system involves many subjects, such as mechanical design and process manufacture, bio-pathology, sensor technology, embedded system and so on. It is a comprehensive subject involving many disciplines. The final goal is to make a fast and fully automatic pathological tissue processing equipment, which can effectively improve the quality of pathological tissue treatment and shorten the time of pathological treatment. Based on the analysis of pathological tissue processing process, a multi-subordinate pathological tissue processing system architecture is constructed. In this paper, the circuit design and program realization of the slave part of the pathological tissue processing system are introduced in detail, and some key technologies in the pathological tissue processing system are also introduced. This paper is mainly divided into the following parts: first, the introduction introduces the subject source and research significance of pathological tissue system, summarizes the current situation of pathological tissue processing system at home and abroad, and draws on the advantages of existing equipment. And hope to carry forward the advantages in the design system and improve the shortcomings of the existing equipment. Secondly, the concept of pathological tissue processing and the workflow of pathological tissue processing are introduced. The main mechanical structure of the pathological tissue management system is analyzed, and the overall planning of the electrical system is carried out. Third, ultrasound oscillation method is used to speed up the process of pathological treatment. The ultrasonic drive circuit is designed, and the problems encountered in the design of the drive circuit are solved step by step. Finally, the optimal driving solution is put forward. The software realization of ultrasonic drive is given. Fourthly, the drive circuit is designed for some switching load in the pathological tissue processing system, and the work flow of the specific function module is designed. In the way of hardware driver, the switching load can be shielded. The subsequent developer can control the switch load directly according to the interface requirement, and do not need to do the tedious work such as driver configuration, etc. And attached the driver source code. Fifthly, the paper verifies the correctness of the circuit design, the transplant of the system, the correctness of the protocol, and the result of the program code. Project team members participate in the joint debugging of the overall pathological tissue management system, including communication testing, and system stability testing for long-term operation. Sixth, to make a summary of the project, and put forward the project needs to be improved.
【學位授予單位】：山東師范大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R361
，

本文編號：2244870