發(fā)布時間：2018-03-18 14:58

  本文選題：自噬　切入點：參與　出處：《中國免疫學(xué)雜志》2013年07期 　論文類型：期刊論文

【摘要】：正細(xì)胞自噬(Autophagy)是真核生物中古老且進(jìn)化保守的對細(xì)胞內(nèi)物質(zhì)進(jìn)行周轉(zhuǎn)的重要過程。最早由Ashford和Porten于1962年用電子顯微鏡觀察人的肝細(xì)胞在加入高血糖素后出現(xiàn)的自食(Self-eat-ing)現(xiàn)象而被發(fā)現(xiàn)[1]。后來人們將該現(xiàn)象命名為自噬。其通過雙層膜包裹部分胞漿和細(xì)胞內(nèi)需要降解的細(xì)胞器、蛋白質(zhì)等成分形成自噬體,后者隨之與溶酶體融合形成自噬溶酶體,并最終將所包裹的內(nèi)容物降解。
[Abstract]:Autophagyis is an ancient and evolutionarily conserved important process in eukaryotes for the turnover of intracellular substances. In 1962, Ashford and Porten first observed the occurrence of autophagyin in human hepatocytes with the addition of glucagon. The phenomenon of eating self-eat-ingwas discovered [1]. It was later named autophagy, which encapsulates part of the cytoplasm and organelles that need to be degraded in the cell through a bilayer membrane. The protein and other components form autophagy which fuses with lysosome to form autophagy and finally degrades the encapsulated contents.
【作者單位】： 浙江大學(xué)免疫研究所;
【基金】：浙江省重大科技專項重點社會發(fā)展項目(2009c13018)資助
【分類號】：R392.1
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本文編號：1630078