【摘要】：目的探討人類白細胞抗原(HLA)-DQA1位點基因多態(tài)性與塵肺病發(fā)病的相關性。方法采用1∶1配比的病例-對照研究方法,選取130例已確診為塵肺病的患者作為塵肺組,另選130例與塵肺組年齡和累計接塵工齡相近、同性別、同民族、同一工作地點的健康接塵工人作為對照組。用多重聚合酶鏈反應-連接酶檢測反應分型法,檢測2組研究對象HLA-DQA1共6個位點的等位基因,并分析其與塵肺病的相關性。結果塵肺組HLA-DQA1*0201和HLA-DQA1*0601基因頻率均高于對照組(14.62%vs 8.85%,12.69%vs 7.31%),而HLA-DQA1*0101基因頻率低于對照組(34.23%vs 43.08%),差異均有統(tǒng)計學意義(P0.05)。Logistic回歸分析顯示,HLA-DQA1*0101、HLA-DQA1*0201和HLA-DQA1*0601等位基因頻率與塵肺病有關聯(lián)(P0.05),優(yōu)勢比分別為0.688、1.764和1.844,95%可信區(qū)間分別為(0.482~0.981)、(1.018~3.055)和(1.019~3.336)。結論 HLA-DQA1*0201和HLA-DQA1*0601基因可能是塵肺病的易感基因,HLA-DQA1*0101基因可能是塵肺病的保護基因。
[Abstract]:Objective to investigate the relationship between (HLA) -DQA1 locus polymorphism of human leukocyte antigen and pneumoconiosis. Methods 130 patients with pneumoconiosis were selected as pneumoconiosis group by using the 1:1 matched case-control study, and 130 patients with pneumoconiosis were selected as the same age and cumulative exposure age, same sex and same nationality. Healthy workers exposed to dust in the same workplace served as the control group. Multiplex polymerase chain reaction-ligase assay was used to detect the alleles of 6 HLA-DQA1 loci in two groups of subjects, and the correlation between the alleles and pneumoconiosis was analyzed. Results the frequencies of HLA-DQA1*0201 and HLA-DQA1*0601 genes in pneumoconiosis group were higher than those in control group (14.62%vs 8.85: 12.69 vs 7.31%), while the frequency of HLA-DQA1*0101 gene was lower than that in control group (34.23%vs 43.08%). The difference was statistically significant (P0.05). Logistic regression analysis showed that the allele frequencies of HLA-DQA1-0101 HLA-DQA1-0201 and HLA-DQA1*0601 were associated with pneumoconiosis (P0.05). The confidence intervals of 0.688), (1.764 and 1.844V 95% were (0.482n) 0.981), (1.018 / 3.055 and (1.019 / 3.336), respectively. Conclusion HLA-DQA1*0201 and HLA-DQA1*0601 genes may be the susceptible genes of pneumoconiosis, and HLA-DQA1O101 gene may be a protective gene for pneumoconiosis.
【作者單位】： 山東省醫(yī)學科學院山東省腫瘤醫(yī)院;濟南大學山東省醫(yī)學科學院醫(yī)學與生命科學學院;淄博市職業(yè)病防治院;
【分類號】：R135.2

【參考文獻】

相關期刊論文 前10條

1 張克菊,魏茂提,何麗,杜�？�,王世鑫;人類白細胞抗原基因多態(tài)性與肺疾病關系[J];國外醫(yī)學.流行病學傳染病學分冊;2005年04期

2 李繼釗;人類白細胞抗原Ⅰ類和Ⅱ類等位基因多態(tài)性與矽肺易感性的研究進展[J];工業(yè)衛(wèi)生與職業(yè)病;2004年03期

3 張金標;孫黎飛;;HLA分子及其與免疫性疾病相關性的研究進展[J];實用醫(yī)藥雜志;2013年06期

4 李津,葉炳杰,商群,莊向,林青;某村石英粉加工工人矽肺病的患病調查[J];中國工業(yè)醫(yī)學雜志;2005年05期

5 王紅英;邢建新;周康;潘澤民;陸林;馬海梅;張慧;張妍;;HLA-DQA1等位基因與新疆哈薩克族原發(fā)性高血壓的相關性[J];西安交通大學學報(醫(yī)學版);2009年04期

6 劉鳳霞;陳艷;白鑫;楊文清;占瓊;崔建華;;HLA-DQA1基因與新疆吐魯番地區(qū)維吾爾族2型糖尿病關聯(lián)性研究[J];現(xiàn)代預防醫(yī)學;2011年18期

7 范雪云;馬慶坤;姚三巧;白玉萍;王永恒;李娟;;肺纖維化相關因子基因多態(tài)性與塵肺病易感性研究[J];中國職業(yè)醫(yī)學;2011年05期

8 許一玲;李秀燕;李萍;蔣春梅;;白細胞抗原基因多態(tài)性與塵肺易感性關系研究進展[J];預防醫(yī)學論壇;2010年07期

9 范雪云,李繼釗,姚三巧,閆進德,李翠蘭,馬慶坤;人類白細胞抗原DRB1和DQB1基因多態(tài)性與塵肺發(fā)病的相關性[J];中華勞動衛(wèi)生職業(yè)病雜志;2005年04期

10 馬政文,楊裕國,黃立東,林琳,陸佩華;IDDM與HLA-DQA1及其啟動子QAP的相關性研究[J];中華微生物學和免疫學雜志;2001年01期

【共引文獻】

相關期刊論文 前10條

1 汪瀚;楊文明;鮑遠程;汪美霞;韓輝;王曉e，

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