本文選題：特發(fā)性肺間質(zhì)纖維化 + 銀杏葉提取物��； 參考：《中國老年學(xué)雜志》2017年22期

【摘要】：目的探討銀杏葉提取物聯(lián)合潑尼松對特發(fā)性肺間質(zhì)纖維化患者細(xì)胞因子及肺纖維化程度的影響。方法特發(fā)性肺間質(zhì)纖維化患者76例,采用隨機數(shù)字表字法分為觀察組與對照組各38例,觀察組給予銀杏葉提取物聯(lián)合潑尼松治療,對照組給予潑尼松治療,對比治療前后兩組腫瘤壞死因子(TNF)-α、白細(xì)胞介素(IL)-4、IL-10、干擾素(IFN)-γ、Ⅲ型前膠原肽(PC-Ⅲ)、Ⅳ型膠原(Ⅳ-C)、透明質(zhì)酸(HA)、層黏連蛋白(LN)水平。結(jié)果兩組治療前TNF-α、IFN-γ、IL-4、IL-10水平比較差異無統(tǒng)計學(xué)意義(P0.05)。兩組治療后IL-4、IL-10、TNF-α水平較治療前均顯著降低,且觀察組顯著低于對照組,IFN-γ水平顯著增加,且觀察組水平顯著高于對照組(均P0.05)。治療前兩組PC-Ⅲ、Ⅳ-C、HA、LN水平比較差異無統(tǒng)計學(xué)意義(P0.05);治療后,兩組均顯著降低,且觀察組顯著低于對照組(均P0.05)。結(jié)論銀杏葉提取物聯(lián)合潑尼松治療特發(fā)性肺間質(zhì)纖維化患者,能夠有效調(diào)節(jié)患者的細(xì)胞因子水平,降低肺纖維化程度。
[Abstract]:Objective to investigate the effect of Ginkgo biloba extract combined with prednisone on the cytokines and the degree of pulmonary fibrosis in patients with idiopathic pulmonary fibrosis. Methods 76 patients with idiopathic pulmonary fibrosis were divided into observation group and control group by random digital expression method, 38 cases were treated with prednisone and Apricot Leaf Extract and control group. Prednisone was treated with two groups of tumor necrosis factor (TNF) - alpha, interleukin (IL) -4, IL-10, interferon (IFN) - gamma, type III procollagen peptide (PC- III), type IV collagen (IV -C), hyaluronic acid (HA), and laminin (LN) level. There was no significant difference in the level of TNF- a, IFN- gamma and IL-4 before treatment of two groups. Two After treatment, the level of IL-4, IL-10, TNF- alpha was significantly lower than that before treatment, and the observation group was significantly lower than the control group, and the level of IFN- gamma was significantly increased, and the level of the observation group was significantly higher than that of the control group (all P0.05). There was no significant difference between the two groups of PC- III, IV -C, HA, and LN (P0.05) before treatment, and the two groups were significantly reduced after treatment, and the observation group was significant. It was lower than the control group (all P0.05). Conclusion Ginkgo biloba extract combined with prednisone can effectively regulate the level of cytokines and reduce the degree of pulmonary fibrosis in patients with idiopathic pulmonary fibrosis.
【作者單位】： 天津市胸科醫(yī)院呼吸與危重癥科;
【分類號】：R563

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