本文選題：中性粒細(xì)胞　切入點(diǎn)：Pelger-Huёt　出處：《臨床檢驗(yàn)雜志》2014年08期

【摘要】：正Pelger-Huёt異常(Pelger-Huёt anomaly,PHA)是一種先天或后天多種原因引起的白細(xì)胞畸形,細(xì)胞形態(tài)在顯微鏡下主要表現(xiàn)為中性粒細(xì)胞核分葉困難、分2葉甚至完全不分葉和過度的染色質(zhì)凝聚的現(xiàn)象。PHA可以是常染色體顯性遺傳,與核纖層蛋白B受體(lamin B receptor,LBR)的基因(LBR)突變密切相關(guān);也可以是后天獲得,即假性PHA,又稱獲得性
[Abstract]:Positive Pelger-Hu abnormality (Pelger-Hu anomaly) is a kind of white blood cell malformation caused by congenital or acquired leukocyte malformation. Under microscope, the cell morphology is mainly characterized by the difficulty of neutrophil nuclear lobulation. PHA may be an autosomal dominant inheritance, closely related to the mutation of the nuclear lamin B receptor LBRs gene, or acquired, or acquired, or acquired.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院檢驗(yàn)科;
【分類號】：R743.3;R563.1
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本文編號：1663163