不同濃度布地奈德聯(lián)合復(fù)方異丙托溴銨對(duì)老年急性加重期慢性阻塞性肺疾病患者動(dòng)脈血?dú)饧胺喂δ艿挠绊?/H1>
發(fā)布時(shí)間：2018-02-23 05:40
本文關(guān)鍵詞： 布地奈德 復(fù)方異丙托溴銨 急性加重期慢性阻塞性肺疾病 動(dòng)脈血?dú)?肺功能 出處：《中國(guó)老年學(xué)雜志》2017年21期
論文類型：期刊論文
【摘要】：目的探討不同濃度布地奈德聯(lián)合復(fù)方異丙托溴銨對(duì)老年急性加重期慢性阻塞性肺疾病(AECOPD)患者動(dòng)脈血?dú)饧胺喂δ艿挠绊�。方法老年AECOPD患者60例,以隨機(jī)數(shù)字表法分為小濃度組與大濃度組各30例。兩組均采取常規(guī)對(duì)癥治療,在此基礎(chǔ)上小濃度組應(yīng)用小濃度布地奈德(2 mg/次,20 min/次,2次/d)霧化吸入聯(lián)合復(fù)方異丙托溴銨治療,大濃度組應(yīng)用大濃度布地奈德(4 mg/次,20 min/次,2次/d)霧化吸入聯(lián)合復(fù)方異丙托溴銨治療,療程均為1 w。觀察對(duì)比兩組臨床療效、治療前后動(dòng)脈血?dú)�、肺功能的變化及不良反�?yīng)情況。結(jié)果大濃度組治療的總有效率高于小濃度組(P0.05)。治療1 w后,大濃度組血氧分壓(PaO_2)高于小濃度組,二氧化碳分壓(PaCO_2)低于小濃度組(均P0.05)。治療1 w后,大濃度組1 s用力呼氣容積(FEV1)、FEV1與用力肺活量比值(FEV1/FVC)均高于小濃度組(P0.05)。兩組不良反應(yīng)率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論大濃度布地奈德聯(lián)合復(fù)方異丙托溴銨治療老年AECOPD患者具有顯著的效果,可以改善患者的動(dòng)脈血?dú)饧胺喂δ?安全性較好。
[Abstract]:Objective to investigate the effects of different concentrations of budesonide combined with compound ipratropium bromide on arterial blood gas and pulmonary function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Two groups were randomly divided into small concentration group (30 cases) and high concentration group (30 cases). Both groups were treated with routine symptomatic therapy. On the basis of this, the small concentration group was treated with small concentration budesonide 2 mg / time 20 min / d) nebulization combined with compound ipratropium bromide. The high concentration group was treated with budesonide 4 mg / d 20 min / d) atomization inhalation combined with compound ipratropium bromide for 1 w.The clinical efficacy of the two groups was observed and compared, and arterial blood gas was obtained before and after treatment. Results the total effective rate of the high concentration group was higher than that of the small concentration group (P 0.05). After 1 week of treatment, the blood oxygen partial pressure of the high concentration group was higher than that of the small concentration group. Paco _ 2 was lower than that in the low concentration group (P 0.05). After 1 week of treatment, Paco _ 2 was significantly lower than that in the low concentration group (P _ (0.05)). The ratio of FEV1 / FVC1 to forced vital capacity (FEV1 / FVC1) in the high concentration group was higher than that in the small concentration group (P 0.05). There was no significant difference in the adverse reaction rate between the two groups. Conclusion there is no significant difference in the adverse reaction rate between the two groups. Conclusion large concentration budesonide combined with compound isoprotopril bromide is effective in the elderly. Patients with AECOPD have significant effects. It can improve arterial blood gas and lung function of patients, and the safety is good.
【作者單位】： 蘇州大學(xué)附屬無(wú)錫九院呼吸內(nèi)科;
【基金】：2016年度無(wú)錫市科技發(fā)展指導(dǎo)性計(jì)劃項(xiàng)目(No.CSZON1623)
【分類號(hào)】：R563.9
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9 謝鋒;;鹽酸氨溴索與異丙托溴銨霧化吸入治療慢性阻塞性肺病患者臨床觀察[J];醫(yī)學(xué)理論與實(shí)踐;2012年01期
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，
本文編號(hào)：1526255
本文鏈接：http://www.sikaile.net/yixuelunwen/huxijib/1526255.html
本文關(guān)鍵詞： 布地奈德 復(fù)方異丙托溴銨 急性加重期慢性阻塞性肺疾病 動(dòng)脈血?dú)?肺功能 出處：《中國(guó)老年學(xué)雜志》2017年21期 論文類型：期刊論文
【摘要】：目的探討不同濃度布地奈德聯(lián)合復(fù)方異丙托溴銨對(duì)老年急性加重期慢性阻塞性肺疾病(AECOPD)患者動(dòng)脈血?dú)饧胺喂δ艿挠绊�。方法老年AECOPD患者60例,以隨機(jī)數(shù)字表法分為小濃度組與大濃度組各30例。兩組均采取常規(guī)對(duì)癥治療,在此基礎(chǔ)上小濃度組應(yīng)用小濃度布地奈德(2 mg/次,20 min/次,2次/d)霧化吸入聯(lián)合復(fù)方異丙托溴銨治療,大濃度組應(yīng)用大濃度布地奈德(4 mg/次,20 min/次,2次/d)霧化吸入聯(lián)合復(fù)方異丙托溴銨治療,療程均為1 w。觀察對(duì)比兩組臨床療效、治療前后動(dòng)脈血?dú)�、肺功能的變化及不良反�?yīng)情況。結(jié)果大濃度組治療的總有效率高于小濃度組(P0.05)。治療1 w后,大濃度組血氧分壓(PaO_2)高于小濃度組,二氧化碳分壓(PaCO_2)低于小濃度組(均P0.05)。治療1 w后,大濃度組1 s用力呼氣容積(FEV1)、FEV1與用力肺活量比值(FEV1/FVC)均高于小濃度組(P0.05)。兩組不良反應(yīng)率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論大濃度布地奈德聯(lián)合復(fù)方異丙托溴銨治療老年AECOPD患者具有顯著的效果,可以改善患者的動(dòng)脈血?dú)饧胺喂δ?安全性較好。
[Abstract]:Objective to investigate the effects of different concentrations of budesonide combined with compound ipratropium bromide on arterial blood gas and pulmonary function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Two groups were randomly divided into small concentration group (30 cases) and high concentration group (30 cases). Both groups were treated with routine symptomatic therapy. On the basis of this, the small concentration group was treated with small concentration budesonide 2 mg / time 20 min / d) nebulization combined with compound ipratropium bromide. The high concentration group was treated with budesonide 4 mg / d 20 min / d) atomization inhalation combined with compound ipratropium bromide for 1 w.The clinical efficacy of the two groups was observed and compared, and arterial blood gas was obtained before and after treatment. Results the total effective rate of the high concentration group was higher than that of the small concentration group (P 0.05). After 1 week of treatment, the blood oxygen partial pressure of the high concentration group was higher than that of the small concentration group. Paco _ 2 was lower than that in the low concentration group (P 0.05). After 1 week of treatment, Paco _ 2 was significantly lower than that in the low concentration group (P _ (0.05)). The ratio of FEV1 / FVC1 to forced vital capacity (FEV1 / FVC1) in the high concentration group was higher than that in the small concentration group (P 0.05). There was no significant difference in the adverse reaction rate between the two groups. Conclusion there is no significant difference in the adverse reaction rate between the two groups. Conclusion large concentration budesonide combined with compound isoprotopril bromide is effective in the elderly. Patients with AECOPD have significant effects. It can improve arterial blood gas and lung function of patients, and the safety is good.
【作者單位】： 蘇州大學(xué)附屬無(wú)錫九院呼吸內(nèi)科;
【基金】：2016年度無(wú)錫市科技發(fā)展指導(dǎo)性計(jì)劃項(xiàng)目(No.CSZON1623)
【分類號(hào)】：R563.9
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 艾斯卡爾·阿布拉;再吐娜·吾布力;;異丙托溴銨輔助治療慢性阻塞性肺疾病的臨床療效[J];中國(guó)醫(yī)學(xué)創(chuàng)新;2013年19期
2 王昆潤(rùn);吸入異丙托溴銨液治療支氣管哮喘急性發(fā)作[J];國(guó)外醫(yī)學(xué).藥學(xué)分冊(cè);1998年04期
3 楊順志;梁日明;黃嫦敏;;國(guó)產(chǎn)異丙托溴銨霧化吸入液治療慢性阻塞性肺疾病的有效性和安全性觀察[J];廣東醫(yī)學(xué)院學(xué)報(bào);2013年01期
4 滕箭;趙煒;王建華;王晶;;吸入用布地奈德混懸液和吸入用異丙托溴銨溶液霧化吸入治療慢性阻塞性肺疾病的療效分析[J];中國(guó)現(xiàn)代醫(yī)藥雜志;2013年04期
5 張宇鋒;;復(fù)方異丙托溴銨霧化吸入治療慢性阻塞性肺疾病臨床觀察[J];齊齊哈爾醫(yī)學(xué)院學(xué)報(bào);2014年08期
6 李磊;張遜;韓洪利;徐醫(yī)軍;韓興鵬;石珍亮;;異丙托溴銨在纖維支氣管鏡檢查中的應(yīng)用[J];天津醫(yī)藥;2012年06期
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8 韓雪峰;乜慶榮;張愛(ài)民;;布地奈德聯(lián)合沙丁胺醇/異丙托溴銨治療慢性阻塞性肺疾病療效觀察[J];臨床肺科雜志;2011年07期
9 謝鋒;;鹽酸氨溴索與異丙托溴銨霧化吸入治療慢性阻塞性肺病患者臨床觀察[J];醫(yī)學(xué)理論與實(shí)踐;2012年01期
10 謝漢華 ,黃謙 ,顧學(xué)仁;鹽酸氨溴素與異丙托溴銨霧化吸入治療對(duì)慢性阻塞性肺病患者肺功能及病程的影響[J];中國(guó)現(xiàn)代醫(yī)學(xué)雜志;2002年19期
相關(guān)會(huì)議論文 前1條
1 韓婧;夏婧;王中新;路蘋;張湘燕;;不同劑量布地奈德聯(lián)合異丙托溴銨霧化吸入治療AECOPD的對(duì)比研究[A];中華醫(yī)學(xué)會(huì)呼吸病學(xué)年會(huì)——2013第十四次全國(guó)呼吸病學(xué)學(xué)術(shù)會(huì)議論文匯編[C];2013年
相關(guān)碩士學(xué)位論文 前1條
1 張連蓮;霧化吸入異丙托溴銨治療慢性阻塞性肺疾病急性加重期的療效觀察[D];吉林大學(xué);2012年
，本文編號(hào)：1526255
本文鏈接：http://www.sikaile.net/yixuelunwen/huxijib/1526255.html
