新輔助順鉑腹腔熱灌注化療治療老年晚期卵巢癌的療效
發(fā)布時間:2019-06-26 20:01
【摘要】:目的探討腹腔熱灌注順鉑治療老年晚期卵巢癌的臨床效果。方法 80例患者分為兩組,各40例,均使用紫杉醇。對照組聯(lián)合順鉑靜注,觀察組聯(lián)合順鉑腹腔熱灌注治療,比較兩組治療過程中CA125水平變化,統(tǒng)計并發(fā)癥發(fā)生率及2年生存率。結果治療后1個周期開始,觀察組CA125水平顯著低于對照組(P0.05),觀察組發(fā)生腎功能損傷和骨髓抑制的比例顯著低于對照組(P0.05),觀察組1年及2年生存率均顯著高于對照組(P0.05)。結論腹腔熱灌注順鉑能顯著提高患者生存率,減少不良反應。
[Abstract]:Objective To investigate the clinical effect of intraperitoneal heat perfusion of cisplatin on advanced ovarian cancer in the elderly. Methods 80 patients were divided into two groups(40 cases each). In the control group, combined with cisplatin intraperitoneal perfusion, CA125 level changes in the two groups were compared. Results The CA125 level in the observation group was significantly lower than that in the control group(P0.05). Conclusion Abdominal thermoperfusion of cisplatin can significantly improve survival and reduce adverse reactions.
【作者單位】: 河北醫(yī)科大學附屬唐山市工人醫(yī)院婦產科;天津醫(yī)科大學總醫(yī)院婦產科;河北醫(yī)科大學附屬唐山市工人醫(yī)院免疫科;
【基金】:唐山市科技局科技支撐指導項目(No.111302097b)
【分類號】:R737.31
[Abstract]:Objective To investigate the clinical effect of intraperitoneal heat perfusion of cisplatin on advanced ovarian cancer in the elderly. Methods 80 patients were divided into two groups(40 cases each). In the control group, combined with cisplatin intraperitoneal perfusion, CA125 level changes in the two groups were compared. Results The CA125 level in the observation group was significantly lower than that in the control group(P0.05). Conclusion Abdominal thermoperfusion of cisplatin can significantly improve survival and reduce adverse reactions.
【作者單位】: 河北醫(yī)科大學附屬唐山市工人醫(yī)院婦產科;天津醫(yī)科大學總醫(yī)院婦產科;河北醫(yī)科大學附屬唐山市工人醫(yī)院免疫科;
【基金】:唐山市科技局科技支撐指導項目(No.111302097b)
【分類號】:R737.31
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相關期刊論文 前3條
1 高麗珍;高峨嵋;白云飛;蘇海龍;;順鉑、多西他賽序貫腹腔熱灌注聯(lián)合靜脈化療在中晚期卵巢癌圍術期的應用[J];解放軍醫(yī)藥雜志;2012年08期
2 牛換萍;;卵巢癌血清HE4、CA72-4、CA125水平測定[J];腫瘤基礎與臨床;2013年06期
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