發(fā)布時(shí)間：2019-01-18 12:29

【摘要】：目的探討雌激素硫酸基轉(zhuǎn)移酶(SULT1E1)和孕激素受體蛋白(PR)在子宮肉瘤組織中的表達(dá)并分析其與子宮肉瘤發(fā)病的相關(guān)性。方法選取2001—2010年中國醫(yī)科大學(xué)附屬盛京醫(yī)院婦產(chǎn)科收治的子宮肉瘤病人石蠟病理切片46例(子宮內(nèi)膜間質(zhì)肉瘤31例,子宮平滑肌肉瘤15例),取宮頸上皮內(nèi)瘤變(CIN)Ⅲ級(jí)或子宮脫垂病人的正常子宮肌層組織石蠟病理切片20例作為對(duì)照。用免疫組化法對(duì)子宮肉瘤組織的SULT1E1、PR蛋白進(jìn)行檢測。結(jié)果子宮內(nèi)膜間質(zhì)肉瘤組及子宮平滑肌肉瘤組分別與正常子宮肌層組SULT1E1蛋白陽性率比較,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05);子宮內(nèi)膜間質(zhì)肉瘤組與子宮平滑肌肉瘤組PRA蛋白、PRB蛋白陽性率比較差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。子宮內(nèi)膜間質(zhì)肉瘤組織中SULT1E1與PRA、PRB蛋白之間均呈負(fù)相關(guān)關(guān)系(分別r=-0.389,P=0.031;r=-0.421,P=0.018)。結(jié)論子宮肉瘤的發(fā)生、發(fā)展與子宮肉瘤組織SULT1E1蛋白表達(dá)降低或缺失有關(guān);在子宮內(nèi)膜間質(zhì)肉瘤組織中SULT1E1的表達(dá)與孕激素受體A、B表達(dá)均呈負(fù)相關(guān)。
[Abstract]:Objective to investigate the expression of estrogen sulfate transferase (SULT1E1) and progesterone receptor protein (PR) in uterine sarcoma and its correlation with the pathogenesis of uterine sarcoma. Methods 46 cases of uterine sarcoma (31 cases of endometrial stromal sarcoma and 15 cases of uterine leiomyosarcoma) were selected from the Department of Obstetrics and Gynecology of Shengjing Hospital affiliated to China Medical University from 2001 to 2010. Paraffin sections of normal myometrium of cervical intraepithelial neoplasia (CIN) 鈪，

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