發(fā)布時間：2018-11-10 20:34

【摘要】：目的:探討不孕癥患者促排卵治療與子宮內膜息肉發(fā)生的關系,闡明促排卵治療中影響子宮內膜息肉發(fā)生的因素。方法:收集于門診行宮腔鏡檢查的76例做過促排卵治療的不孕患者,分析不孕類型、不孕年限、促排卵治療周期數和促排卵治療中是否應用過促性腺激素釋放激素類似物(GnRHa)與子宮內膜息肉發(fā)生的關系。結果:在促排卵治療的不孕患者中,不同不孕類型患者間子宮內膜息肉發(fā)生率比較差異無統(tǒng)計學意義(χ2=0.071,P=0.790);不同不孕年限患者間子宮內膜息肉發(fā)生率比較差異無統(tǒng)計學意義(χ2=1.561,P=0.458);而不同促排卵治療周期數患者間子宮內膜息肉發(fā)生率比較差異有統(tǒng)計學意義(χ2=4.992,P=0.025);促排卵治療中是否應用過GnRHa患者間子宮內膜息肉發(fā)生率比較差異有統(tǒng)計學意義(χ2=18.899,P=0.000)。在經過促排卵治療的患者中,隨著促排治療周期數的增加,不孕患者子宮內膜息肉的發(fā)生率增加,經過3個以上促排卵治療周期的不孕患者子宮內膜息肉發(fā)生率高于經過1~2個促排卵治療周期者(52.4%vs25.5%,P=0.025)。在促排卵治療中應用過GnRHa的不孕患者子宮內膜息肉發(fā)生率明顯低于未應用過GnRHa的患者(16.0%vs 65.4%,P=0.000)。結論:促排卵治療周期數的增加是不孕患者子宮內膜息肉發(fā)病的相關危險因素,而GnRHa可抑制不孕患者子宮內膜息肉的發(fā)生。
[Abstract]:Objective: to investigate the relationship between ovulation promotion therapy and endometrial polyp in infertile women, and to elucidate the factors affecting the occurrence of endometrial polyps in ovulation promotion therapy. Methods: 76 infertile patients who had been treated with ovulation promotion were collected from the outpatient department for hysteroscopy, and the type of infertility and the length of infertility were analyzed. The relationship between the number of cycles of ovulation and the use of gonadotropin releasing hormone analogue (GnRHa) in ovulation induction therapy and the occurrence of endometrial polyps. Results: there was no significant difference in the incidence of endometrial polyps among the infertile patients with different infertility types (蠂 ~ 2 / 0.071P ~ (0.790). There was no significant difference in the incidence of endometrial polyps among patients with different infertile years (蠂 2 1.561 P < 0. 458). The incidence of endometrial polyps in patients with different cycles of ovulation promotion was significantly different (蠂 ~ 2 = 4.992P ~ 0. 025). There was a significant difference in the incidence of endometrial polyps between the patients who had been treated with GnRHa during ovulation promotion (蠂 2 / 18.899P = 0.000). The incidence of endometrial polyps in infertile women increased with the number of cycles of ovulation promotion treatment. The incidence of endometrial polyps in infertile women after more than 3 cycles of ovulation promotion treatment was higher than that in those after 1 ~ 2 cycles of ovulation promotion treatment (52.4 vs 25.5P0. 025). The incidence of endometrial polyps in infertile women who had been treated with GnRHa during ovulation promotion was significantly lower than that in patients without GnRHa (16.0%vs 65.4% P0. 000). Conclusion: the increase of the number of ovulatory treatment cycles is the risk factor of endometrial polyps in infertile patients, while GnRHa can inhibit the occurrence of endometrial polyps in infertile patients.
【作者單位】： 吉林大學第二醫(yī)院婦產科;吉林大學基礎醫(yī)學院組織學與胚胎學系;
【基金】：吉林省科技廳科技發(fā)展計劃項目資助課題(20130413026GH)
【分類號】：R711.6

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