宮頸非典型鱗狀上皮細(xì)胞、人乳頭狀瘤病毒聯(lián)合宮頸多點(diǎn)活檢及宮頸管搔刮診斷老年宮頸疾病的價(jià)值
發(fā)布時(shí)間:2018-10-05 08:05
【摘要】:目的通過(guò)對(duì)宮頸細(xì)胞學(xué)檢查結(jié)果為非典型鱗狀上皮細(xì)胞(ASU-US)的中老年患者進(jìn)行人乳頭狀瘤病毒(HPV)聯(lián)合宮頸多點(diǎn)活檢及宮頸管搔刮(ECC)檢查的診斷價(jià)值。方法系統(tǒng)性回顧分析≥55歲的262例宮頸ASCUS患者的液基細(xì)胞學(xué)、高危型HPV定量檢測(cè)(HC2-HPV DNA)、陰道鏡檢查和組織病理學(xué)檢查資料。結(jié)果組織病理學(xué)確診情況,良性病變177例(67.56%)、宮頸上皮內(nèi)瘤變(CIN)Ⅰ38例(14.5%)、CINⅡ18例(6.87%)、CINⅢ23例(8.78%)和浸潤(rùn)性癌6例(2.29%)。相應(yīng)的HC2-HPV DNA陽(yáng)性率分別為9.6%(17/177),55.26%(21/38),88.89%(16/18),95.45%(21/23)和100%(6/6)。ECC所得的組織病理學(xué)為高級(jí)別鱗狀上皮內(nèi)病變(HSIL)6例,而對(duì)應(yīng)患者活檢完整組織塊病理學(xué)結(jié)果分別為低級(jí)別鱗狀上皮內(nèi)病變(LSIL)和良性病變。HPV陽(yáng)性組≥CINⅡ的檢出率53.09%(44/81),陰性組為0(0/181),二者差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論宮頸細(xì)胞學(xué)檢查為ASC-US的患者中存在不小比例的HSIL(CINⅡ和CINⅢ),甚至浸潤(rùn)性癌。陰道鏡下宮頸活檢+宮頸管搔術(shù)有助于診斷,防止漏診。對(duì)ASC-US患者及時(shí)進(jìn)行HC2-HPV DNA檢測(cè),可作為ASC-US患者的分流手段,并采取規(guī)范診療措施能有效地發(fā)現(xiàn)潛在的HSIL或浸潤(rùn)性癌病變。
[Abstract]:Objective to evaluate the diagnostic value of human papillomavirus (HPV) (HPV) combined with cervical multipoint biopsy and cervix curettage (ECC) examination in elderly patients with atypical squamous epithelial cells (ASU-US). Methods the liquid-based cytology, high risk HPV quantitative examination (HC2-HPV DNA), colposcopy and histopathological examination) of 262 patients with cervical ASCUS (鈮,
本文編號(hào):2252625
[Abstract]:Objective to evaluate the diagnostic value of human papillomavirus (HPV) (HPV) combined with cervical multipoint biopsy and cervix curettage (ECC) examination in elderly patients with atypical squamous epithelial cells (ASU-US). Methods the liquid-based cytology, high risk HPV quantitative examination (HC2-HPV DNA), colposcopy and histopathological examination) of 262 patients with cervical ASCUS (鈮,
本文編號(hào):2252625
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