發(fā)布時(shí)間：2018-09-18 14:49

【摘要】：目的：探討女性生殖道人乳頭狀瘤病毒(Human Papillomaviruses, HPV)感染與生殖道其它常見病原體感染的關(guān)系。方法：收集2011年8月至2013年8月在新疆醫(yī)科大學(xué)第二附屬醫(yī)院婦產(chǎn)科住院患者HPV分型一種亞型或多種亞型呈陽(yáng)性的患者73例,HPV分型亞型呈陰性患者80例,兩組患者均進(jìn)行沙眼衣原體、解脲支原體、細(xì)菌性陰道病、假絲酵母菌和陰道毛滴蟲的檢測(cè),統(tǒng)計(jì)分析檢測(cè)結(jié)果,了解生殖道HPV感染與其它病原體感染有無(wú)相關(guān)性。結(jié)果：HPV呈陽(yáng)性的73例患者中,15例為HPV多種亞型混合感染,其余58例為單一的HPV亞型感染,其中中高危型HPV陽(yáng)性者占71.2%,檢出率較高的為HPV52型、16型、53型、66型；低危型HPV陽(yáng)性者占8.2%,主要有6型、11型、43型。HPV陽(yáng)性組和HPV陰性組與生殖道其它病原體感染單因素比較：解脲支原體感染與HPV感染具有顯著性意義(X2=5.19,P0.05),其它病原體感染與HPV感染不具有顯著性意義。Logistic回歸分析結(jié)果顯示：生殖道解脲支原體感染與HPV感染具有相關(guān)性(OR=2.401,95%CI為1.173～4.914,P0.05),解脲支原體是HPV感染的危險(xiǎn)因素；生殖道沙眼衣原體、細(xì)菌性陰道病、假絲酵母菌、陰道毛滴蟲感染與HPV感染無(wú)相關(guān)性(P均0.05)。結(jié)論：生殖道解脲支原體感染與HPV感染具有相關(guān)性,解脲支原體感染可增加HPV感染；沙眼衣原體、細(xì)菌性陰道病、假絲酵母菌、陰道毛滴蟲感染與HPV感染無(wú)明顯相關(guān)性。
[Abstract]:Objective: to investigate the relationship between human papillomavirus (Human Papillomaviruses, HPV) infection in female genital tract and other common pathogens in genital tract. Methods: from August 2011 to August 2013, a total of 73 patients with positive subtype or subtypes of HPV were selected from the second affiliated Hospital of Xinjiang Medical University, Department of Gynecology and Obstetrics. Chlamydia trachomatis, Ureaplasma Urealyticum, bacterial vaginosis, Candida cerevisiae and Trichomonas vaginalis were detected in both groups. Results among 73 cases with positive HPV, 15 cases were mixed infection of HPV subtype, the other 58 cases were single HPV subtype infection. The high risk HPV positive cases accounted for 71.2%. Low risk type HPV positive group accounted for 8.2%. There were 6 type 11 type 43. HPV-positive group and HPV negative group compared with the single factor of other pathogens infection in the reproductive tract: Ureaplasma Urealyticum infection and HPV infection had significant significance (X2P 5.19 P 0.05), other pathogens infection had significant significance (X2P 5.19 P 0.05), and other pathogens were infected with Ureaplasma Urealyticum infection and HPV infection. Logistic regression analysis showed that Ureaplasma Urealyticum infection was correlated with HPV infection (OR=2.401,95%CI = 1.173, 4.914, P0.05). Ureaplasma Urealyticum was the risk factor of HPV infection. There was no correlation between chlamydia trachomatis, bacterial vaginosis, Candida cerevisiae, trichomonas vaginalis infection and HPV infection (all P 0.05). Conclusion: Ureaplasma Urealyticum infection is related to HPV infection, Ureaplasma Urealyticum infection can increase HPV infection, but Chlamydia trachomatis, bacterial vaginosis, Candida cerevisiae, Trichomonas vaginalis infection and HPV infection have no significant correlation.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R711.31

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