【摘要】：目的統(tǒng)計(jì)≥30歲維吾爾族婦女不同型別人乳頭瘤病毒(human papillomavivus,HPV)感染和宮頸細(xì)胞學(xué)檢查結(jié)果,分析不同型別HPV感染發(fā)生高度宮頸病變(≥CIN2)的風(fēng)險(xiǎn),為規(guī)范化管理未發(fā)生宮頸病變和HPV陽性的婦女提供理論依據(jù)。方法收集2012-01-01-2014-02-28新疆維吾爾自治區(qū)人民醫(yī)院婦產(chǎn)科不同型別HPV感染且宮頸細(xì)胞學(xué)檢查未見異常的維吾爾族婦女199例,根據(jù)不同HPV型別進(jìn)行分組,常規(guī)全部行陰道鏡檢查,行宮頸多點(diǎn)活檢組織病理學(xué)檢查,根據(jù)病檢結(jié)果分析各個(gè)型別宮頸高度病變的患病率,運(yùn)用Logistic回歸分析不同型別HPV婦女發(fā)生高度宮頸病變的風(fēng)險(xiǎn)。結(jié)果 199例宮頸細(xì)胞學(xué)檢查未見異常,但HPV分型檢測(cè)15種高危型HPV陽性的維吾爾族婦女中感染位居前5位的為HPV16、58、52、53和31型。其中高度宮頸病變的患病率為18.59%(37/199),HPV陽性的各個(gè)型別中診斷≥CIN2級(jí)病變有HPV 16、58、52、31和18型,HPV16型陽性患者發(fā)生≥CIN2級(jí)病變的患病率為38.48%(20/58),HPV58型陽性的患病率為30.23%(13/43),HPV52型的患病率為5.90%(2/34),HPV31型陽性的患病率為3.70%(1/27),HPV18型陽性的患病率為11.11%(1/9)。HPV16型感染發(fā)生≥CIN2級(jí)的危險(xiǎn)是無HPV16型感染者的3.839倍,95%CI為1.829~8.060,P0.001;HPV58型感染發(fā)生≥CIN2級(jí)的危險(xiǎn)是無HPV58型感染者的2.365倍,95%CI為1.476~7.669,P=0.004。結(jié)論對(duì)于≥30歲維吾爾族婦女宮頸細(xì)胞學(xué)檢查未見異常但高危型HPV陽性者尤其是HPV16和58型陽性者,發(fā)生宮頸高度病變的風(fēng)險(xiǎn)較高,應(yīng)行陰道鏡檢查,必要時(shí)做活檢。
[Abstract]:Objective to analyze the risk of human papillomavirus (CIN2) infection and cervical cytology in Uygur women aged more than 30 years. To provide theoretical basis for standardized management of women without cervical lesions and HPV positive. Methods 199 Uygur women with different types of HPV infection in gynaecology and obstetrics department in Xinjiang Uygur Autonomous region people's Hospital were collected from 2012-01-01-2014-02-28. According to different types of HPV, 199 women of Uygur nationality were divided into groups according to different types of HPV, and all of them were examined with colposcopy. Histopathological examination of cervical multipoint biopsy was performed to analyze the prevalence rate of high cervical lesions in different types of HPV according to the results of pathological examination. Logistic regression analysis was used to analyze the risk of high cervical lesions in women with different types of HPV. Results there was no abnormality in cervical cytology in 199 cases, but among the 15 high risk HPV positive Uygur women detected by HPV typing, the top 5 were HPV161658-52C53 and 31. The prevalence rate of high cervical lesions was 18.59% (37 / 199) in all types of HPV-positive lesions 鈮，

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