【摘要】：卵巢癌是婦科常見的惡性腫瘤,發(fā)病率高,預(yù)后差,多數(shù)患者發(fā)現(xiàn)時已是晚期,卵巢癌目前公認(rèn)的治療方法是腫瘤細(xì)胞減滅手術(shù)配合化療。手術(shù)是一個損傷正氣的過程,而化療藥物作用于腫瘤細(xì)胞的同時對正常細(xì)胞也有毒性作用,引起相應(yīng)的毒副反應(yīng),主要表現(xiàn)有骨髓抑制、消化道反應(yīng)、神經(jīng)毒性等,使機(jī)體難以耐受甚至不得不中斷治療。近年來,中醫(yī)中藥相關(guān)治療的研究也越來越多,在治療腫瘤化療后的毒副反應(yīng)上有一定療效,能夠幫助機(jī)體提高免疫力,更好的配合治療。就近幾年中醫(yī)在治療卵巢癌術(shù)后化療后的臨床研究上,本文對其作了一個文獻(xiàn)型研究。 目的：通過對近年有關(guān)中醫(yī)治療卵巢癌術(shù)后化療后的文獻(xiàn)進(jìn)行研究,探討中醫(yī)對卵巢癌術(shù)后化療后病機(jī)的認(rèn)識,以及中藥治療的用藥規(guī)律。 方法：以CNKI知識數(shù)據(jù)庫、萬方數(shù)據(jù)知識平臺、維普中文科技期刊數(shù)據(jù)庫為檢索工具,搜索1990年1月至2014年2月有關(guān)卵巢癌的中醫(yī)臨床研究文獻(xiàn),篩選出中醫(yī)結(jié)合卵巢癌化療的臨床文獻(xiàn)。對文獻(xiàn)中所用的中藥以類別、功效、性味、歸經(jīng)、頻率等內(nèi)容建立數(shù)據(jù)庫,運用Excel軟件建立數(shù)據(jù)庫并進(jìn)行分類統(tǒng)計。 結(jié)果：根據(jù)資料來源及檢索方法,共獲得124篇文獻(xiàn),依照本文前面所述納入標(biāo)準(zhǔn),篩選出符合標(biāo)準(zhǔn)的文獻(xiàn)27篇,所有文獻(xiàn)中涉及病例數(shù)1201例,收集方劑共35首,所用藥物116味,藥物共出現(xiàn)410次,所使用次數(shù)14225人次。 1.根據(jù)文獻(xiàn)中出現(xiàn)的證型看,卵巢癌術(shù)后化療后患者以氣陰兩虛型最多,達(dá)35.22%,其次是氣虛血瘀型21.4%,脾虛濕困型17.24%。 2.根據(jù)所使用藥物頻率得出,藥物使用率排名前10位依次為黃芪、白術(shù)、茯苓、黨參、甘草、白花蛇舌草、半枝蓮、當(dāng)歸、薏苡仁、莪術(shù)。 3.根據(jù)藥物歸類看,藥物出現(xiàn)次數(shù)最多的為補虛藥,占38.29%；其次是清熱藥,占15.61%；活血化瘀藥占12.93%。 4.根據(jù)藥物藥性及歸經(jīng)看,出現(xiàn)最多的藥性為平性藥,藥味為甘味,歸經(jīng)最多的為脾經(jīng)。 結(jié)論：卵巢癌術(shù)后化療后以虛證為多,治療以補虛為主,清熱解毒、活血化瘀為輔。
[Abstract]:Ovarian cancer is a common gynecological malignant tumor with high incidence and poor prognosis. Surgery is a process of damage to qi, and chemotherapy drugs also have toxic effects on normal cells when they act on tumor cells, causing the corresponding toxic and side effects, such as bone marrow suppression, digestive tract reaction, neurotoxicity and so on. Make the body difficult to tolerate or even have to interrupt treatment. In recent years, there are more and more researches on TCM related treatment, which has a certain curative effect on the side effects of tumor chemotherapy, which can help the body to improve immunity and better cooperate with treatment. In this paper, a literature study on the treatment of ovarian cancer after chemotherapy was carried out in this paper. Objective: to study the literature on the treatment of ovarian cancer by traditional Chinese medicine (TCM) after chemotherapy in recent years, and to explore the understanding of the pathogenesis of postoperative chemotherapy of ovarian cancer and the rule of traditional Chinese medicine (TCM) in the treatment of ovarian cancer. Methods: using CNKI knowledge database, Wanfang data knowledge platform and Weipu Chinese science and technology periodical database as the retrieval tools, we searched for the literature of TCM clinical research on ovarian cancer from January 1990 to February 2014. The clinical literature of Chinese medicine combined with ovarian cancer chemotherapy was screened out. The database of traditional Chinese medicine used in literature was established with the contents of category, efficacy, sexual taste, meridian, frequency and so on. The database was established by using Excel software and classified statistics were carried out. Results: according to the data sources and retrieval methods, a total of 124 articles were obtained. According to the inclusion criteria mentioned in the previous article, 27 articles were selected to meet the criteria. 1201 cases were involved in all the literatures, 35 prescriptions were collected and 116 kinds of drugs were used. The drug appeared 410 times, the number of times used was 14225. 1. According to the syndrome types appeared in the literature, the most of the patients with ovarian cancer after chemotherapy were deficiency of Qi and Yin (35.22), followed by deficiency of Qi and Blood stasis (21.442), spleen deficiency of dampness (17.2442) and stagnation of dampness (17.24.2). According to the frequency of the drugs used, the top 10 places of drug use rate were Astragalus, Atractylodes macrocephala, Poria cocos, Codonopsis, Glycyrrhiza, Scutellaria barbata, Angelica sinensis, Coix seed, Curcuma. According to the classification of drugs, the most frequent occurrence of drugs was deficiency drugs (38.29), followed by heat-clearing drugs (15.61%) and blood circulation drugs (12.933.4%). According to the medicinal properties and classics, the most common drugs were flat drugs, sweet taste and spleen meridian. Conclusion: deficiency syndrome is the main treatment for ovarian cancer after chemotherapy, the main treatment is tonifying deficiency, clearing heat and detoxifying, activating blood circulation and removing blood stasis.
【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R737.31

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