發(fā)布時間：2018-04-15 08:20

  本文選題：卵巢交界性腫瘤 + 保守��； 參考：《蘭州大學》2017年碩士論文

【摘要】：目的:系統(tǒng)評價卵巢交界性腫瘤(Borderline Ovarian Tumors,BOTs)保守手術術后復發(fā)的危險因素,為臨床治療和隨訪提供依據(jù)。方法:計算機檢索PubMed、EMbase、The Cochrane Library(2016年第12期)、Web of Science、CNKI、CBM、WanFang Data、VIP等數(shù)據(jù)庫,搜集所有研究卵巢交界性腫瘤保守手術術后復發(fā)危險因素的隊列研究或病例對照研究,檢索時限均從建庫至2016年12月31日,同時手工檢索相關國內期刊雜志,由2位研究員按照納入、排除標準獨立篩選文獻、提取資料并評價納入研究的偏倚風險后,采用RevMan5.3軟件進行Meta分析。結果:全文最終納入20個隊列研究,共1064例患者。Meta分析結果顯示:在術后復發(fā)率方面,FIGO≥Ⅱ期和FIGOⅠ期[OR=3.32,95%CI(1.56,7.05),P=0.002]、雙側卵巢腫瘤和單側卵巢腫瘤[OR=3.51,95%CI(1.73,7.10),P=0.0005]、卵巢囊腫切除術和單側附件切除術[OR=2.88,95%CI(1.82,4.56),P0.00001]、腫瘤包膜破裂和腫瘤包膜未破裂[OR=8.93,95%CI(2.73,29.20),P=0.0003]、交界性漿液性卵巢腫瘤(Serous Borderline Ovarian Tumors,SBOT)和交界性黏液性卵巢腫瘤(Mucinous Borderline Ovarian Tumors,MBOT)[OR=2.21,95%CI(1.49,3.28),P0.0001]、微乳頭浸潤和無微乳頭浸潤[OR=2.36,95%CI(1.32,4.24),P=0.004]的術后復發(fā)率差異有統(tǒng)計學意義,而FIGOⅠC期和FIGO≤ⅠB期[OR=1.32,95%CI(0.74,2.33),P=0.34]、術前CA125升高和術前CA125正常[OR=1.37,95%CI(0.53,3.53),P=0.51]、腹腔鏡手術和開腹手術[OR=1.27,95%CI(0.88,1.85),P=0.20]、分期手術和未分期手術[OR=0.38,95%CI(0.11,1.26),P=0.11]、清掃淋巴結和未清掃淋巴結[OR=1.21,95%CI(0.34,4.30),P=0.77]、微浸潤和無微浸潤[OR=1.25,95%CI(0.69,2.25),P=0.46]、術后化療和術后未化療[OR=1.12,95%CI(0.43,2.90),P=0.81]對術后復發(fā)率的影響無統(tǒng)計學差異。結論:FIGO≥Ⅱ期、雙側卵巢腫瘤、卵巢囊腫切除術、腫瘤包膜破裂、SBOT、微乳頭浸潤是卵巢交界性腫瘤保守手術術后復發(fā)的危險因素。
[Abstract]:Objective: to evaluate the risk factors for recurrence of borderline Ovarian tumors after conservative surgery, and to provide evidence for clinical treatment and follow-up.Methods: a computer-based search of the Cochrane Library (issue 12 of 2016) was conducted to collect all cohort studies or case-control studies on the risk factors of recurrence of ovarian borderline tumors after conservative surgery.The time limit for retrieval was from the establishment of the database to December 31, 2016, and the relevant domestic periodical magazines were manually searched, which were included by two researchers, excluding the criteria for independent screening of literature, extracting data and evaluating the bias risks involved in the study.Meta analysis was carried out with RevMan5.3 software.Results: the full text was included in 20 cohort studies.鑰孎IGO鈪燙鏈熷拰FIGO鈮も厾B鏈焄OR=1.32,95%CI(0.74,2.33),P=0.34],鏈墠CA125鍗囬珮鍜屾湳鍓岰A125姝ｅ父[OR=1.37,95%CI(0.53,3.53),P=0.51],鑵硅厰闀滄墜鏈拰寮，

本文編號：1753299