本文選題：補腎調(diào)沖祛瘀方 + 人絨毛膜促性腺激素　； 參考：《河南中醫(yī)學院》2014年碩士論文

【摘要】：目的：觀察補腎調(diào)沖祛瘀方聯(lián)合人絨毛膜促性腺激素(human chorionicgonadotropin，HCG)和黃體酮對腎虛血瘀型抗心磷脂抗體(anti cardiolipin antibody，ACA)陽性所致早期復發(fā)性流產(chǎn)(recurrent spontaneous abortion，RSA)患者在中醫(yī)癥候、ACA轉(zhuǎn)陰率、保胎成功率、血清人絨毛膜促性腺激素(serum human chorionic gonadotropin，β-HCG)及孕酮(Progesterone，P)水平方面的影響；探討補腎調(diào)沖祛瘀方聯(lián)合HCG和黃體酮對腎虛血瘀型ACA陽性所致早期RSA的作用機理，為補腎調(diào)沖祛瘀方聯(lián)合HCG和黃體酮治療腎虛血瘀型ACA陽性所致早期RSA提供客觀詳實的依據(jù)。 方法：按照整群抽樣的方法，收集2012.10~2013.12期間就診于河南中醫(yī)學院第一附屬醫(yī)院婦產(chǎn)科門診及住院部的ACA陽性所致早期RSA患者50例。分為兩組：治療組30例，以補腎調(diào)沖祛瘀方聯(lián)合HCG和黃體酮治療；對照組20例，以HCG和黃體酮治療。評定兩組患者治療前后中醫(yī)證候積分、血清β-HCG及P的變化情況；檢測用藥后ACA轉(zhuǎn)陰率、保胎成功率的情況。 結(jié)果：治療組治療前后中醫(yī)證候積分經(jīng)檢驗，差異有統(tǒng)計學意義(P＜0.05)，對照組治療前后差異有統(tǒng)計學意義(P＜0.05)，兩組治療前后差值經(jīng)檢驗差異有統(tǒng)計學意義(P＜0.05)。治療后患者療效指數(shù)分布情況治療組較對照組差異有統(tǒng)計學意義(P＜0.05)。治療組ACA轉(zhuǎn)陰26人，有效率86.7%；對照組ACA轉(zhuǎn)陰12人，有效率60.0%，差異有統(tǒng)計學意義(P＜0.05)。治療組保胎成功26人，有效率86.7%；對照組保胎成功11人，有效率55.0%，差異有統(tǒng)計學意義（P＜0.05）。治療組治療前后血清β-HCG及P，，差異有統(tǒng)計學意義(P＜0.05)，對照組治療前后差異有統(tǒng)計學意義(P＜0.05)。兩組治療前后差值經(jīng)檢驗差異無統(tǒng)計學意義(P＞0.05)。 結(jié)論：①補腎調(diào)沖祛瘀方聯(lián)合HCG和黃體酮對ACA陽性所致早期RSA患者具有較好的干預效果,能改善患者的腎虛血瘀證侯，提高ACA轉(zhuǎn)陰率、增加保胎成功率；②補腎調(diào)沖祛瘀方聯(lián)合HCG和黃體酮能改善患者血清β-HCG及P水平。
[Abstract]:Objective: to observe the effect of Bushen Tiaochong Quyu recipe combined with human chorionic gonadotropin (HCG) and progesterone on early recurrent abortion induced by anti-cardiolipid antibody anti anti cardiolipin antibody-ACAA positive in patients with kidney deficiency and blood stasis syndrome.The effect of serum human chorionic gonadotropin (尾 -HCG) and progesterone Progesteroneone (P) on serum levels of serum human chorionic gonadotropin (尾 -HCG), to explore the mechanism of Bushen Tiaochong Quyu decoction combined with HCG and progesterone on early RSA induced by ACA positive of kidney deficiency and blood stasis type.It provides an objective and detailed basis for the treatment of early RSA caused by ACA positive of kidney deficiency and blood stasis type by Bushen Tiaochong Quyu recipe combined with HCG and progesterone.Methods: according to the method of cluster sampling, 50 patients with early RSA caused by ACA positive in gynecology and obstetrics department of the first affiliated Hospital of Henan College of traditional Chinese Medicine were collected from February 10 to December 2012.30 cases in the treatment group were treated with Bushen Tiaochong Quyu decoction combined with HCG and progesterone, and 20 cases in the control group were treated with HCG and progesterone.The changes of TCM syndromes, serum 尾 -HCG and P were evaluated before and after treatment, the conversion rate of ACA and the success rate of fetal preservation were detected.Results: the scores of TCM syndromes before and after treatment in the treatment group were significantly different (P < 0.05), the difference in the control group was significant (P < 0.05), and the difference between the two groups before and after treatment was statistically significant (P < 0.05).The distribution of curative effect index in the treatment group was significantly higher than that in the control group (P < 0.05).In the treatment group, 26 cases of ACA turned negative, the effective rate was 86.7%, while in the control group, ACA turned to negative in 12 cases, the effective rate was 60.0, the difference was statistically significant (P < 0.05).In the treatment group, 26 cases were successfully preserved and the effective rate was 86.7%, while in the control group, 11 cases were successfully preserved, the effective rate was 55.0%, the difference was statistically significant (P < 0.05).The difference of serum 尾 -HCG and Pin before and after treatment in the treatment group was statistically significant (P < 0.05), while that in the control group was significant (P < 0.05).There was no significant difference between the two groups before and after treatment (P > 0.05).Conclusion Bushen Tiaochong Quyu decoction combined with HCG and progesterone has better intervention effect on early RSA patients caused by positive ACA. It can improve the kidney deficiency and blood stasis syndrome, increase the negative rate of ACA, and increase the success rate of fetal preservation.2Bushen Tiaochong Quyu decoction combined with HCG and progesterone could improve serum 尾 -HCG and P levels.
【學位授予單位】：河南中醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R714.21

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