本文選題：子宮頸癌　切入點：危險因素　出處：《吉林大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:本文對近17年國內外公開報道的獨立的關于中國女性子宮頸癌發(fā)病相關危險因素的原始數據進行Meta分析,為我國子宮頸癌的預防及控制提供循證依據。方法:通過檢索中英文數據庫,收集國內外2000年1月至2017年3月公開發(fā)表的我國女性子宮頸癌發(fā)病相關危險因素的文獻資料。經過文獻篩選后對最終納入文獻的數據進行提取,使用軟件Rev Man5.3處理所提取的數據。對所納入的文獻進行異質性的檢驗,如果所得的結果顯示P0.10,I250%,則說明各研究間同質性較好,選用固定效應模式來分析數據;若所得的結果顯示P0.10,I250%,則選擇隨機效應模型對數據進行分析。結果:嚴格按照納入及排除標準對文獻進行篩選,最終納入22篇文獻,經評定均≥6分,提取其中13項與子宮頸癌發(fā)病相關的因素進行綜合分析。Meta分析結果表明:高危型人乳頭瘤病毒(HR-HPV)感染合并比值比OR=169.29,95%可信區(qū)間(95%CI)為[34.34,834.62];單純皰疹Ⅱ型病毒(HSV-Ⅱ)感染合并比值比OR=5.83,95%可信區(qū)間(95%CI)為[2.73,12.47];衣原體感染合并比值比OR=3.88,95%可信區(qū)間(95%CI)為[2.47,6.10];滴蟲感染合并比值比OR=2.65,95%可信區(qū)間(95%CI)為[1.72,4.07];細菌性陰道病合并比值比OR=5.67,95%可信區(qū)間(95%CI)為[4.00,8.04];真菌感染合并比值比OR=4.58,95%可信區(qū)間(95%CI)為[1.54,13.60];初次性生活年齡≤20歲合并比值比OR=2.53,95%可信區(qū)間(95%CI)為[1.09,5.85];口服避孕藥合并比值比OR=0.30,95%可信區(qū)間(95%CI)為[0.07,1.24];絕經合并比值比OR=1.72,95%可信區(qū)間(95%CI)為[1.05,2.81];被動吸煙合并比值比OR=2.38,95%可信區(qū)間(95%CI)為[1.66,3.43];血清葉酸含量高合并比值比OR=0.49,95%可信區(qū)間(95%CI)為[0.35,0.70];口服多種維生素合并比值比OR=0.58,95%可信區(qū)間(95%CI)為[0.41,0.81];腫瘤家族史合并比值比OR=2.09,95%可信區(qū)間(95%CI)為[1.58,2.75]。結論:1、生殖道感染與中國女性子宮頸癌的發(fā)生有明顯相關性,HR-HPV、HSV-Ⅱ、衣原體、滴蟲、細菌性陰道病、真菌感染是中國女性子宮頸癌發(fā)生的危險因素,其中HR-HPV感染是主要的危險因素。2、初次性生活年齡≤20歲、絕經、被動吸煙、腫瘤家族史是中國女性子宮頸癌發(fā)生的危險因素。3、血清葉酸含量高、口服多種維生素是中國女性子宮頸癌發(fā)生的保護因素。4、口服避孕藥并不增加中國女性子宮頸癌發(fā)生的風險。
[Abstract]:Objective: to analyze the risk factors associated with cervical cancer in Chinese women by Meta analysis, which was published in recent 17 years at home and abroad. To provide evidence-based evidence for the prevention and control of cervical cancer in China. To collect the literature on the risk factors related to cervical cancer in women published in China from January 2000 to March 2017. Using the software Rev Man5.3 to process the extracted data. The heterogeneity of the included documents is tested. If the results obtained show that the homogeneity of each study is good, the fixed effect model is chosen to analyze the data. If the results show that P0.10 / I250, then the random effect model is selected to analyze the data. Results: according to the criteria of inclusion and exclusion, the literature was screened, and 22 articles were included, all of which were evaluated as 鈮，

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