本文關鍵詞： 粘連 宮腔粘連 戊酸雌二醇 分離術　出處：《山東醫(yī)藥》2015年21期 　論文類型：期刊論文

【摘要】：目的觀察大劑量戊酸雌二醇在重度宮腔粘連分離術后預防再粘連的效果。方法選擇行宮腔粘連分離術的重度宮腔粘連患者236例,隨機分為觀察組和對照組各118例,術后觀察組口服戊酸雌二醇10 mg/d、對照組口服戊酸雌二醇5 mg/d,兩組均于服用戊酸雌二醇第12天追加地屈孕酮10 mg/d口服,繼續(xù)服藥10 d,停藥9 d后繼續(xù)下個療程,連續(xù)治療3個療程。術前及術后3個月檢測兩組凝血功能、血脂及肝功能指標,于術后6個月評價治療效果及再粘連情況。結果術后6個月,觀察組總有效率(95.76%)高于對照組(82.20%),觀察組、對照組未見粘連帶分別為71例(60.17%)、45例(38.14%),兩組比較差異有統(tǒng)計學意義(P均0.01)。兩組術前及術后3個月凝血功能、血脂及肝功能指標均在正常范圍內,比較差異均無統(tǒng)計學意義(P均0.05)。在服藥期間兩組均未出現(xiàn)血栓性疾病、皮膚瘀斑、出血點等。結論重度宮腔粘連分離術后應用大劑量戊酸雌二醇可降低再粘連的發(fā)生率。
[Abstract]:Objective to observe the effect of high dose estradiol valerate on preventing readhesions after seperation of severe intrauterine adhesions. Methods 236 patients with severe intrauterine adhesions were randomly divided into observation group (n = 118) and control group (n = 118). After operation, estradiol valerate 10 mg / d in the observation group and estradiol valerate 5 mg / d in the control group were taken orally. Both groups were given diproprogesterone for 10 mg/d on the 12th day after taking estradiol valerate. After 9 days, the next course of treatment was continued. After 3 consecutive courses of treatment, coagulation function, blood lipid and liver function were measured before and 3 months after operation, and the therapeutic effects and adhesions were evaluated 6 months after operation. The total effective rate of observation group was higher than that of control group (82.20%). In the observation group, there were 71 cases (60.17) and 45 cases (38.14%) without adhesion zone in the control group. The difference between the two groups was statistically significant (P < 0.01). The coagulation function of the two groups before and 3 months after operation was significantly higher than that in the control group (P < 0.05). The indexes of blood lipid and liver function were within the normal range, and there was no significant difference between the two groups (P < 0.05). There were no thrombotic diseases and skin ecchymosis in the two groups during the treatment period. Conclusion large dose of estradiol valerate can reduce the incidence of re-adhesion after seperation of severe intrauterine adhesions.
【作者單位】： 曹縣人民醫(yī)院;
【分類號】：R713.4

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