本文選題：手機(jī)成癮 + 基于體素的形態(tài)學(xué)分析��； 參考：《臨床放射學(xué)雜志》2017年10期

【摘要】：目的研究手機(jī)依賴者大腦灰質(zhì)結(jié)構(gòu)的變化,探討手機(jī)依賴者大腦灰質(zhì)結(jié)構(gòu)改變的特征。方法 25名手機(jī)依賴癥者與23名健康對照者參加本研究,采用西門子3.0 T Trio MRI掃描儀對全腦灰質(zhì)(3D T1_mprage)進(jìn)行數(shù)據(jù)采集,使用基于體素的形態(tài)學(xué)分析(VBM)方法觀察手機(jī)依賴組與正常被試組之間的灰質(zhì)結(jié)構(gòu)的差異,采用雙樣本t檢驗分析兩組差異,并進(jìn)行Alpha Sim校正,取個數(shù)115的體素集合,校正后P0.01的像素被認(rèn)為具有顯著性。結(jié)果與正常組相比,手機(jī)依賴組多個腦區(qū)的灰質(zhì)體積縮小,主要包括中央前回、旁中央小葉、額上回、眶額部皮層、背側(cè)前扣帶回、島葉、基底節(jié)區(qū)的尾狀核、殼核、蒼白球、杏仁核和丘腦、伏隔核、中腦腹側(cè)被蓋區(qū)、海馬等區(qū)域。結(jié)論手機(jī)依賴癥者與正常對照組相比,在上述區(qū)域的灰質(zhì)結(jié)構(gòu)已發(fā)生變化。提示手機(jī)依賴癥可能影響了與認(rèn)知功能、沖動控制、情緒和精神行為、大腦獎賞等功能相關(guān)腦區(qū)的灰質(zhì)結(jié)構(gòu)。
[Abstract]:Objective to study the changes of gray matter structure in the brain of mobile phone dependent patients and to explore the characteristics of gray matter structure changes in the brain of mobile phone dependent patients. Methods A total of 25 patients with mobile phone dependence and 23 healthy controls were enrolled in this study. The data were collected from the whole brain by Siemens 3.0 T Trio MRI scanner. The difference of gray matter structure between mobile phone dependent group and normal group was observed by using morphologic analysis based on voxel. The difference between the two groups was analyzed by double sample t-test. The Alpha Sim correction was performed and the set of voxels was collected. The corrected P0.01 pixels are considered significant. Results compared with the normal group, the gray matter volume of multiple brain regions in the mobile phone dependent group was reduced, including precentral gyrus, paraspinal lobule, superior frontal gyrus, orbital frontal cortex, dorsal anterior cingulate gyrus, island lobe, caudate nucleus, putamen nucleus and globus pallidus of basal ganglia area. Amygdala and thalamus, nucleus accumbens, ventral tegmental area of midbrain, hippocampus and so on. Conclusion the gray matter structure in the above areas has changed in the patients with mobile phone dependence compared with the normal control group. These results suggest that mobile phone dependence may affect the gray matter structure of brain regions related to cognitive function, impulse control, emotional and mental behavior, and brain reward.
【作者單位】： 深圳市中醫(yī)院放射影像科;中國科學(xué)院深圳先進(jìn)技術(shù)研究院;
【基金】：深圳市科技計劃項目基金資助(編號:JCYJ20150401163247205)
【分類號】：R445.2;R749
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本文編號：1963134