【摘要】：目的分析血小板相關(guān)指標(biāo)對(duì)于超低出生體質(zhì)量?jī)?ELBW)動(dòng)脈導(dǎo)管未閉(PDA)的早期預(yù)測(cè)價(jià)值。方法回顧分析2013年6月至2016年6月收治的79例ELBW患兒,其中無(wú)PDA48例(nPDA組),PDA 31例(PDA組);31例PDA患兒中,無(wú)血流動(dòng)力學(xué)意義的PDA(nhsPDA組)17例,有血流動(dòng)力學(xué)意義的PDA(hsPDA組)14例。比較nPDA組與PDA組,以及nhsPDA組與hsPDA組的臨床特征及血小板相關(guān)指標(biāo),采用多元logistic回歸模型分析各因素對(duì)PDA發(fā)生的影響。采用ROC曲線分析相關(guān)指標(biāo)對(duì)PDA的早期預(yù)測(cè)價(jià)值。結(jié)果與nPDA組相比較,PDA組胎齡小,男嬰比例高,血小板分布寬度(PDW)小,差異有統(tǒng)計(jì)學(xué)意義(P均0.05)。多元logistic回歸分析提示PDW越低,發(fā)生PDA風(fēng)險(xiǎn)越大(OR=1.26,95%CI:1.05~1.52)。ROC曲線分析發(fā)現(xiàn),PDW最佳診斷界值為13.4 GSD,對(duì)PDA早期預(yù)測(cè)靈敏度為67.74%,特異度為68.75%。hsPDA組胎齡小于nhsPDA組,剖宮產(chǎn)比例低于nhsPDA組,差異有統(tǒng)計(jì)學(xué)意義(P均0.05),hsPDA組與nhsPDA組間血小板相關(guān)指標(biāo)差異無(wú)統(tǒng)計(jì)學(xué)意義(P均0.05)。結(jié)論 PDW對(duì)ELBW的PDA具有一定的早期預(yù)測(cè)價(jià)值,伴PDW13.4 GSD的ELBW,需高度警惕PDA。
[Abstract]:Objective to analyze the early predictive value of platelet related indexes in (ELBW) patent ductus arteriosus (PDA) in ultra-low birth weight infants. Methods from June 2013 to June 2016, 79 cases of ELBW were retrospectively analyzed, including no PDA48 (31 cases of), PDA in nPDA group (PDA group). Among the 31 cases of PDA, 17 cases were in PDA (nhsPDA group without hemodynamic significance and 14 cases in PDA (hsPDA group with hemodynamic significance. The clinical characteristics and platelet related indexes of nPDA group and PDA group, nhsPDA group and hsPDA group were compared, and the influence of various factors on PDA was analyzed by multivariate logistic regression model. The early prediction value of PDA was analyzed by ROC curve. Results compared with nPDA group, PDA group had smaller gestational age, higher ratio of male infants and smaller platelet distribution width (PDW) (P < 0. 05). Multiple logistic regression analysis showed that the lower the PDW was, the greater the risk of PDA was (OR=1.26,95%CI:1.05~1.52). ROC curve analysis showed that the best diagnostic threshold of PDW was 13.4 GSD, and the sensitivity to early PDA prediction was 67.74. 4%). The specificity of 68.75%.hsPDA group was lower than that of nhsPDA group, and the ratio of cesarean section was lower than that of nhsPDA group (P 0.05). There was no significant difference in platelet related indexes between nhsPDA group and), hsPDA group (P 0.05). Conclusion PDW has early predictive value for PDA of ELBW. ELBW, with PDW13.4 GSD should be on high alert to PDA..
【作者單位】： 廣東省婦幼保健院;
【分類號(hào)】：R722.6

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