【摘要】：目的：探討黃芪注射液對急性淋巴細胞白血病(ALL)誘導(dǎo)緩解化療期間患兒感染相關(guān)因素的影響。方法：采用隨機雙盲法將91例ALL患兒分為治療組(47例)和對照組(44例),治療組在誘導(dǎo)緩解化療的同時給予加用黃芪注射液0.5mL／kg.d,共35d,對照組給予同等劑量生理鹽水代替,兩組其他支持治療相同,比較兩組誘導(dǎo)緩解化療結(jié)束后患兒感染的發(fā)生率、感染持續(xù)時間、白細胞及中性粒細胞水平、感染部位及分泌物病原菌培養(yǎng)陽性率等。結(jié)果：治療組47例患兒中有4例出現(xiàn)過敏反應(yīng)后退出實驗,研究顯示誘導(dǎo)緩解化療后治療組患兒的感染發(fā)生率均低于對照組(均P0.05)；不同感染部位的感染持續(xù)時間均低于對照組(均P0.05)；治療組中性粒細胞水平均高于對照組(均P0.05)；治療組呼吸道感染、泌尿道感染、血液感染及皮膚軟組織感染發(fā)生率均低于對照組(均P0.05)；感染病原菌以革蘭陰性菌為主,感染患兒中治療組分泌物培養(yǎng)陽性率低于對照組(P0.05)。結(jié)論：黃芪注射液可能在誘導(dǎo)緩解化療期間減輕了化療藥物對骨髓的抑制,也可能通過提高中性粒細胞水平,從而使ALL患兒在誘導(dǎo)緩解化療期間感染發(fā)生率降低,感染發(fā)生時持續(xù)時間縮短。
[Abstract]:Objective: to investigate the effect of astragalus injection on the infection related factors in children with acute lymphoblastic leukemia (ALL) induced chemotherapy. Methods: 91 children with ALL were randomly divided into treatment group (47 cases) and control group (44 cases). The control group was given the same dose of saline instead of other supportive therapy. The incidence of infection, duration of infection, leukocyte and neutrophil levels were compared between the two groups after induction and remission chemotherapy. The positive rate of pathogenic bacteria culture in infection sites and secretions, etc. Results: 4 of 47 children in the treatment group had allergic reaction and withdrew from the experiment. The incidence of infection in the treatment group after induced remission chemotherapy was lower than that in the control group (P0.05). The duration of infection in different infection sites was lower than that in control group (P0.05), and the level of neutrophil in treatment group was higher than that in control group (P0.05). The incidence of respiratory tract infection, urinary tract infection, blood infection and skin soft tissue infection in the treatment group were lower than those in the control group (P0.05). Gram-negative bacteria were the main pathogens of infection, and the positive rate of secretion culture in the treatment group was lower than that in the control group (P0.05). Conclusion: Astragalus injection may reduce the inhibition of bone marrow induced by chemotherapeutic agents or increase the level of neutrophils during the induction and remission of chemotherapy, so that the incidence of infection in children with ALL may be reduced during the induction and remission of chemotherapy. The duration of infection was shortened.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R733.7

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