【摘要】：目的探討中國(guó)新生兒先天性心臟病(CHD)的主要危險(xiǎn)因素,為CHD的預(yù)防提供參考依據(jù)。方法系統(tǒng)搜集2001~2016年研究中國(guó)新生兒CHD危險(xiǎn)因素的病例對(duì)照研究,提取相關(guān)數(shù)據(jù),按照NOS量表對(duì)納入文獻(xiàn)進(jìn)行質(zhì)量評(píng)價(jià),敏感性分析采用不同模型分析同一資料,采用Egger's檢驗(yàn)評(píng)估發(fā)表偏倚。結(jié)果共納入17篇病例對(duì)照研究,其中病例組2 930例,對(duì)照組4 952例。Meta分析顯示中國(guó)新生兒CHD主要危險(xiǎn)因素為:孕母高齡(OR=2.649,95%CI:1.675~4.189)、感冒或發(fā)燒(OR=4.558,95%CI:2.901~7.162)、孕早期用藥(OR=3.961,95%CI:2.816~5.573)、被動(dòng)吸煙(OR=2.766,95%CI:1.982~3.859)、不良生育史(OR=2.992,95%CI:1.529~5.856)、接觸噪聲(OR=3.030,95%CI:1.476~6.217)、受到輻射(OR=2.363,95%CI:1.212~4.607)、居室新裝修(OR=4.979,95%CI:3.240~7.653)、孕期糖尿病(OR=5.090,95%CI:3.132~8.274)、飼養(yǎng)寵物(OR=2.048,95%CI:1.385~3.029)。結(jié)論孕母高齡、感冒或發(fā)燒、孕早期用藥、被動(dòng)吸煙、不良生育史、接觸噪聲、受到輻射、居室新裝修、孕期糖尿病、飼養(yǎng)寵物可能增加新生兒CHD的患病風(fēng)險(xiǎn)。
[Abstract]:Objective to explore the main risk factors of neonatal congenital heart disease (CHD) in China and to provide reference for the prevention of CHD. Methods A case-control study was conducted to study the risk factors of neonatal CHD in China from 2001 to 2016, and the relevant data were extracted. The quality of the literature was evaluated according to the NOS scale. The sensitivity analysis used different models to analyze the same data. Publication bias was evaluated by Egger's test. Results A total of 17 case-control studies were conducted, including 2 930 cases in the case group and 4 952 cases in the control group. Meta analysis showed that the main risk factors of neonatal CHD in China were: OR=2.649,95%CI:1.675~4.189. Cold or fever (OR=4.558,95%CI:2.901~7.162), early pregnancy medication (OR=3.961,95%CI:2.816~5.573), passive smoking (OR=2.766,95%CI:1.982~3.859), bad birth history (OR=2.992,95%CI:1.529~5.856), Exposure noise (OR=3.030,95%CI:1.476~6.217), exposure to radiation (OR=2.363,95%CI:1.212~4.607), room renovation (OR=4.979,95%CI:3.240~7.653), gestational diabetes mellitus (OR=5.090,95%CI:3.132~8.274), Keep pets (OR=2.048,95%CI:1.385~3.029). Conclusion elderly pregnant mothers, cold or fever, drug use in early pregnancy, passive smoking, bad birth history, exposure to noise, exposure to radiation, newly decorated rooms, diabetes during pregnancy, keeping pets may increase the risk of neonatal CHD.
【作者單位】： 徐州醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;新鄉(xiāng)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院;徐州醫(yī)科大學(xué)護(hù)理學(xué)院;徐州醫(yī)科大學(xué)附屬醫(yī)院兒科;
【基金】：江蘇高校哲學(xué)社會(huì)科學(xué)研究一般項(xiàng)目(2015SJB414)
【分類號(hào)】：R722.1

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本文編號(hào)：2364877