本文選題：缺鐵性貧血 + 紅細(xì)胞參數(shù)��； 參考：《南京醫(yī)科大學(xué)學(xué)報(自然科學(xué)版)》2017年11期

【摘要】：目的:探討異常紅細(xì)胞形態(tài)學(xué)和紅細(xì)胞參數(shù)檢查結(jié)合骨髓鐵染色及血清鐵蛋白在兒童缺鐵性貧血診斷中的應(yīng)用價值。方法:對388例缺鐵性貧血(iron deficiency anemia,IDA)患兒進(jìn)行了異常紅細(xì)胞形態(tài)檢驗并進(jìn)行血清鐵蛋白(serum ferritin,SF)含量檢測,還對其骨髓涂片進(jìn)行鐵染色檢查。選取388例IDA及255例慢性病性貧血(chronic diseases anemia,ACD)患者進(jìn)行平均紅細(xì)胞體積(mean corpuscular volume,MCV)、平均紅細(xì)胞血紅蛋白量(mean corpuscular hemoglobin,MCH)、紅細(xì)胞平均血紅蛋白濃度(mean corpuscular hemoglobin concentration,MCHC)、紅細(xì)胞分布寬度(red blood cell distribution width,RDW)和SF的檢測,并與203例健康對照比較,對結(jié)果進(jìn)行統(tǒng)計學(xué)分析。結(jié)果 :388例IDA患兒異常形態(tài)紅細(xì)胞占56.25%~92.34%,骨髓細(xì)胞鐵染色隨血清鐵蛋白檢測指標(biāo)的增高而增高。與ACD組比較,IDA組MCV、MCH、SF均明顯降低,RDW增高,差異有統(tǒng)計學(xué)意義(P0.05);與對照組比較,IDA組MCV、SF明顯降低,ACD組MCV無明顯變化,SF明顯增高,差異有統(tǒng)計學(xué)意義(P0.05);MCV、RDW和SF三項聯(lián)合診斷IDA的敏感性最高,達(dá)99.9%。MCV、RDW和SF聯(lián)合應(yīng)用可在IDA診斷與鑒別診斷中發(fā)揮更大作用。結(jié)論:異常紅細(xì)胞形態(tài)學(xué)和紅細(xì)胞參數(shù)檢查結(jié)合骨髓鐵染色及血清鐵蛋白在兒童IDA鑒別診斷中有臨床參考價值。
[Abstract]:Objective: To investigate the value of abnormal erythrocyte morphology and erythrocyte parameter examination combined with bone marrow iron staining and serum ferritin in the diagnosis of iron deficiency anemia in children. Methods: the abnormal erythrocyte morphology of 388 iron deficiency anemia (IDA) children and the content of serum ferritin (serum ferritin, SF) were carried out. The average red blood cell volume (mean corpuscular volume, MCV), the average red blood cell hemoglobin (mean corpuscular hemoglobin, IDA), and the average hemoglobin concentration of red blood cells were selected in 388 Cases of IDA and 255 cases of chronic diseases anemia (ACD). Hemoglobin concentration, MCHC), the detection of red blood cell distribution width (red blood cell distribution width, RDW) and SF, and compared with 203 healthy controls, the results were statistically analyzed. Results: 388 Cases of IDA children with abnormal morphologic red cells accounted for 56.25%~92.34%, bone marrow cell iron staining increased with the increase of serum ferritin detection index. Compared with the ACD group, IDA group MCV, MCH, SF were significantly decreased, RDW increased, the difference was statistically significant (P0.05). Compared with the control group, IDA group MCV, SF obviously decreased, ACD group MCV had no significant changes, and the difference was statistically significant. A diagnosis and differential diagnosis play a greater role. Conclusion: abnormal erythrocyte morphology and erythrocyte parameter examination, combined with bone marrow iron staining and serum ferritin, have clinical reference value in the differential diagnosis of children's IDA.
【作者單位】： 南京醫(yī)科大學(xué)附屬兒童醫(yī)院檢驗科;
【基金】：南京醫(yī)科大學(xué)科技發(fā)展基金(2010njmu128)
【分類號】：R446.11;R725.5

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