本文選題：孟魯司特 + 玉屏風顆粒　； 參考：《中國臨床藥理學雜志》2017年17期

【摘要】：目的觀察孟魯司特片聯(lián)合玉屏風顆粒治療兒童過敏性紫癜的臨床療效及安全性。方法將130例過敏性紫癜患兒隨機分為對照組65例和試驗組65例。對照組予以口服孟魯司特,3~4歲4 mg·d~(-1),6歲以上5 mg·d~(-1),每晚睡前給藥一次;試驗組在對照組治療的基礎上,予以口服玉屏風顆粒,3~7歲每次2.5 g,7~14歲每次5 g,tid。2組患者均治療3個月。比較2組患兒的臨床療效、復發(fā)率,以及藥物不良反應的發(fā)生情況。結果治療后,試驗組和對照組的總有效率分別為93.84%(61/65例)和75.38%(49/65例),復發(fā)率分別為0(0/65例)和15.38%(10/65例),差異均有統(tǒng)計學意義(均P0.05)。試驗組發(fā)生的藥物不良反應主要有頭暈、腹瀉、發(fā)熱,對照組發(fā)生的藥物不良反應主要有發(fā)熱、惡心、頭暈、胸悶。試驗組和對照組的藥物不良反應發(fā)生率分別為6.15%和7.69%,差異無統(tǒng)計學意義(P0.05)。結論孟魯司特片聯(lián)合玉屏風顆粒治療兒童過敏性紫癜的臨床療效確切,且不增加藥物不良反應的發(fā)生率。
[Abstract]:Objective to observe the efficacy and safety of montelukast combined with Yupingfeng granule in the treatment of allergic purpura in children. Methods 130 children with Henoch-Schonlein purpura were randomly divided into control group (n = 65) and experimental group (n = 65). The control group was treated with oral montelukast 3 years 4 years old 4 mg d ~ (-1), 5 mg d ~ (-1) every night before bedtime, and the experimental group was treated for 3 months with 5 g / d ~ (-2) of 5 g / d ~ (-1) at the age of 2. 5 g / time, 7 years old and 7 years old, on the basis of the treatment in the control group. The clinical efficacy, recurrence rate and adverse drug reaction were compared between the two groups. Results after treatment, the total effective rates were 93.84% (61 / 65 cases) and 75.38% (49 / 65 cases), respectively, and the recurrence rates were 0 (0 / 65 cases) and 15.38% (10 / 65 cases) in the experimental group and the control group, respectively (P0.05). The main adverse drug reactions in the test group were dizziness, diarrhea and fever, while in the control group there were fever, nausea, dizziness and chest tightness. The incidence of adverse drug reactions in the test group and control group was 6.15% and 7.69% respectively, the difference was not statistically significant (P0.05). Conclusion Montelukast tablet combined with Yupingfeng granule is effective in the treatment of children with Henoch-Schonlein purpura and does not increase the incidence of adverse drug reactions.
【作者單位】： 濟南市兒童醫(yī)院皮膚科;
【基金】：國家醫(yī)學教育發(fā)展中心醫(yī)學研究課題基金資助項目(2010-13-01-064)
【分類號】：R725.5

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