本文選題：社區(qū)獲得性肺炎 + 肺炎支原體肺炎��； 參考：《東南大學(xué)》2015年碩士論文

【摘要】：目的：本文旨在總結(jié)中國東部地區(qū)一家三級醫(yī)院中,兒童肺炎支原體肺炎(Mycoplasma Pneumoniae pneumonia, MPP)的主要臨床表現(xiàn)及實驗室檢查特點；探討該病的發(fā)生率及其與喘息的相關(guān)性；并探索肺炎支原體(Mycoplasma Pneumoniae, MP)感染與兒童哮喘的潛在關(guān)系。方法：本研究回顧性分析了2013年1月1日至2013年12月30日住院的3個月至15歲的社區(qū)獲得性肺炎(community acquired pneumonia, CAP)患兒的臨床資料。肺炎的診斷標(biāo)準(zhǔn)為具有發(fā)熱和/或急性呼吸道癥狀(咳嗽、氣促、呼吸困難等),以及胸部影像學(xué)檢查發(fā)現(xiàn)新的浸潤病灶。急性MP感染由臨床表現(xiàn)和血清學(xué)陽性檢查結(jié)果和/或咽拭子培養(yǎng)陽性決定。所有病例依此分為兩組：MPP組和非MPP組。血液學(xué)檢查包括：IgE和MP特異性的IgG、IgM。人口統(tǒng)計學(xué)資料包括年齡、性別。應(yīng)用配對t檢驗或卡方檢驗對數(shù)據(jù)進行統(tǒng)計學(xué)分析。結(jié)果：咳嗽、喘息、咽痛這三個癥狀在兩組之間差異具有統(tǒng)計學(xué)意義(P0.05,P0.05,P0.01)。與非MPP患兒相比,MPP組IgE上升(100IU/dl)的患兒更多,差異具有統(tǒng)計學(xué)意義(P0.01)；發(fā)生喘息的患兒更多,差異具有統(tǒng)計學(xué)意義(P0.05)。結(jié)論：本研究證實喘息常常與MP感染所致的兒童CAP相關(guān)。類似的,IgE升高在MP陽性患兒更常見,表明體內(nèi)存在過度的免疫反應(yīng),而喘息是免疫介導(dǎo)的氣道高反應(yīng)性所產(chǎn)生的,因此MP感染可能在兒童的特應(yīng)性體質(zhì)及哮喘發(fā)生中起著一定的作用。
[Abstract]:Objective: to summarize the main clinical manifestations and laboratory characteristics of Mycoplasma pneumoniae Pneumoniae pneumonia, MPP) in a tertiary hospital in eastern China, and to explore the incidence of Mycoplasma pneumoniae and its correlation with wheezing. To explore the potential relationship between Mycoplasma pneumoniae (MPI) infection and childhood asthma. Methods: the clinical data of patients with community acquired pneumonia (acquired pneumonia, CAP) from January 1, 2013 to December 30, 2013, aged from 3 months to 15 years, were retrospectively analyzed. The diagnostic criteria for pneumonia are fever and / or acute respiratory symptoms (cough, shortness of breath, dyspnea, etc.), as well as chest imaging findings of new invasive lesions. Acute MP infection is determined by clinical manifestations and seropositive results and / or pharyngeal swab culture. All cases were divided into two groups: MPP group and non-MPP group. Hematologic examination included the specific IgGG of IgE and MP IgM. Demographic data include age and sex. The data were statistically analyzed by paired t test or chi-square test. Results: the three symptoms of cough, wheezing and sore throat were significantly different between the two groups. Compared with the non-MPP group, there were more patients with 100 IUU / dll in MPP group, the difference was statistically significant (P0.01), and the incidence of wheezing was more (P0.05%) in MPP group than that in non-MPP group. Conclusion: this study confirms that wheezing is often associated with CAP in children with MP infection. Similar elevated IgE levels are more common in MP positive children, suggesting an excessive immune response in the body, while wheezing is caused by immune-mediated airway hyperresponsiveness. MP infection may play an important role in children's atopic constitution and asthma.
【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R725.6

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