本文選題：淋巴細胞　切入點：細菌感染　出處：《中國全科醫(yī)學(xué)》2017年S2期

【摘要】：目的建立細菌合并病毒混合感染給予抗生素治療后處于恢復(fù)期的3個月~5歲患兒淋巴細胞比率的參考范圍,并初步探討其有關(guān)影響因素。方法收集高密市婦幼保健院2006年5月—2016年5月住院治療經(jīng)咽拭子細菌、病毒檢測,確診為細菌合并病毒感染的上呼吸道感染的3個月~5歲的患兒1 000例,收集全部研究對象的臨床資料,應(yīng)用SPSS 17.0對檢驗結(jié)果進行統(tǒng)計分析。結(jié)果本研究共收集3個月~5歲患兒1 000例,均為細菌合并病毒感染,其中男596例,女404例。3個月~1歲組恢復(fù)期淋巴細胞比率與其他年齡組比較,差異有統(tǒng)計學(xué)意義(P0.05);其他年齡組恢復(fù)期淋巴細胞比率比較,差異無統(tǒng)計學(xué)意義(P0.05)。入院前淋巴細胞比率、中性粒細胞比率與恢復(fù)期淋巴細胞比率有相關(guān)性(P0.05)。是否應(yīng)用單磷酸阿糖腺苷、大環(huán)內(nèi)酯類藥物的患兒恢復(fù)期淋巴細胞比率比較,差異有統(tǒng)計學(xué)意義(P0.05)。Logistic回歸分析顯示,應(yīng)用大環(huán)內(nèi)酯類藥物(OR=0.393,P=0.032)是促進恢復(fù)期淋巴細胞比率降低的因素。根據(jù)是否應(yīng)用此類藥物分別確定其參考范圍,應(yīng)用大環(huán)內(nèi)酯類藥物患兒恢復(fù)期淋巴細胞比率為(57.38 12.14)%,即(45.244%~69.516%);未應(yīng)用大環(huán)內(nèi)酯類藥物患兒恢復(fù)期淋巴細胞比率為(63.74 10.09%)%,即(53.647%~73.833%)。結(jié)論是否應(yīng)用大環(huán)內(nèi)酯類對恢復(fù)期淋巴細胞比率有影響,參考范圍應(yīng)根據(jù)是否應(yīng)用大環(huán)內(nèi)酯類分別確立,便于指導(dǎo)臨床。
[Abstract]:Objective to establish the reference range of lymphocyte ratio of children aged 5 years old who were in convalescence stage after antibiotic treatment with mixed infection of bacteria and virus, and to explore the influencing factors.The clinical data of all the subjects were collected and the results were statistically analyzed by SPSS 17.0.The difference was statistically significant (P 0.05), but there was no significant difference in other age groups (P 0.05).The lymphocyte ratio, neutrophil ratio and lymphocyte ratio in convalescent stage were correlated with the ratio of lymphocyte before admission (P 0.05).The percentage of lymphocytes in children with adenosine arabinomonophosphate and macrolides in convalescent stage was significantly higher than that in children treated with adenosine arabinoate monophosphate and macrolides. Logistic regression analysis showed that,The application of macrolide 0.393Pu 0.032 was a factor to promote the decrease of lymphocyte ratio in convalescent stage.Conclusion the effect of macrolides on lymphocyte ratio in convalescent stage should be determined according to whether macrolides are used or not, so as to guide clinical practice.
【作者單位】： 濰坊醫(yī)學(xué)院;高密市婦幼保健院;濰坊市人民醫(yī)院;
【分類號】：R725.1

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