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  本文關鍵詞： 熄風止動沖劑 抽動穢語綜合征 臨床觀察 平肝熄風　出處：《黑龍江中醫(yī)藥大學》2013年碩士論文　論文類型：學位論文

【摘要】：目的：觀察熄風止動沖劑治療兒童抽動穢語綜合征的臨床療效 方法：將60例入選患兒按就診順序隨機分為兩組,實驗組和治療組各30例,實驗組給予熄風止動沖劑口服,對照組給予鹽酸硫必利片口服采用耶魯抽動癥整體嚴重程度量表(YGTSS)評分法及中醫(yī)證候為指標,臨床對比觀察了熄風止動沖劑和鹽酸硫必利片對抽動穢語綜合征患者抽動癥狀及中醫(yī)證候的改善情況,觀察其不良反應。 結果：1.兩組治療前分別和治療4周、8周后進行組內(nèi)比較,耶魯抽動積分前后差異均有高度統(tǒng)計學意義(P＜0.01),兩組治療4周后和治療8周后分別進行組內(nèi)比較,耶魯抽動積分前后差異均有高度統(tǒng)計學意義(P0.01)。兩組治療前、治療4周后和8周后分別進行組間比較,耶魯抽動積分差異無統(tǒng)計學意義(P0.05)。 2.實驗組與對照組治療前與治療4、8周后分別進行組內(nèi)比較,治療組中醫(yī)證候積分差異均有高度統(tǒng)計學意義(P0.01),而對照組差異無統(tǒng)計學(P0.05)。治療后4周和治療后8周進行組間比較,實驗組中醫(yī)證候積分差異有高度統(tǒng)計學意義(P0.01)。 3.對照組在嗜睡、頭暈、乏力、心率加快方面,不同程度的出現(xiàn),實驗組2例出現(xiàn)消化道反應,實驗組和對照組在頭暈、乏力方面比較有統(tǒng)計學意義(P0.05)。 結論：1.實驗組和對照組能明顯改善抽動抽動穢語綜合征患兒的抽動癥狀,并且療效相當,治療8周的療效較4周更為顯著。 2.熄風止動沖劑能顯著的改善患兒的中醫(yī)證候,而鹽酸硫必利則無顯著效果。 3.熄風止動沖劑安全、無副作用,而鹽酸硫必利則可出現(xiàn)不同程度的副作用。
[Abstract]:Objective: to observe the clinical effect of Xifeng Zhihe granule on children with Tourette syndrome. Methods: 60 children were randomly divided into two groups: experimental group (n = 30) and treatment group (n = 30). The control group was given tiapride hydrochloride orally with YGTSS score and TCM syndrome as the index. The improvement of symptoms and syndromes of Tourette syndrome in patients with Tourette's syndrome by Xifeng Zhifei granules and tiapride hydrochloride tablets were compared and the adverse reactions were observed. Results before and after 4 weeks and 8 weeks of treatment, there were significant differences in Yale tic score between the two groups (P < 0.01). The differences between the two groups were compared after 4 weeks of treatment and 8 weeks after treatment. The difference of Yale tic score before and after treatment was statistically significant (P 0.01). Before treatment, 4 weeks after treatment and 8 weeks after treatment, there was no significant difference in Yale tic score between the two groups (P 0.05). 2.Compared with the control group before treatment and 4 weeks after treatment, the difference of TCM syndromes in the treatment group was highly statistically significant (P 0.01), but there was no significant difference in the control group (P 0.05). The difference between the two groups was compared 4 weeks after treatment and 8 weeks after treatment. The difference of TCM syndromes in the experimental group was statistically significant (P 0.01). 3. In the control group, there were different degrees of drowsiness, dizziness, fatigue and heart rate acceleration. In the experimental group, there were 2 cases of digestive tract reaction, while in the experimental group and the control group, there were significant differences in dizziness and fatigue (P 0.05). Conclusion1.The experimental group and the control group can obviously improve the symptoms of Tourette syndrome, and the curative effect is similar, and the curative effect is more obvious in the 8th week than in the 4th week. 2. Xifengzhi granule can significantly improve TCM syndromes of children, but thiapride hydrochloride has no significant effect. 3. Xifeng Zhi granule is safe and has no side effects, while thiopride hydrochloride can have different side effects.
【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R272

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