本文選題：咪達唑侖　切入點：山羊　出處：《中國獸醫(yī)雜志》2017年10期 　論文類型：期刊論文

【摘要】：為了研究咪達唑侖對山羊各腦區(qū)單胺類神經遞質的影響,探討咪達唑侖的作用部位及機制。將25只山羊隨機分為5組,分別為對照組、誘導組、麻醉組、恢復Ⅰ組和恢復Ⅱ組。連續(xù)觀察山羊行為學變化,并于相應時間點采取腦組織,通過高效液相色譜(HPLC)法檢測5-羥色胺(5-HT)、5-羥吲哚乙酸(5-HIAA)、去甲腎上腺素(NE)和多巴胺(DA)的含量。結果顯示,咪達唑侖主要作用部位是大腦和腦干,使5-HT和5-HIAA的含量升高,NE和DA的含量降低。
[Abstract]:In order to study the effect of midazolam on monoamine neurotransmitters in different brain regions of goats and to explore the site and mechanism of midazolam, 25 goats were randomly divided into 5 groups: control group, induction group and anesthetic group. The behavioral changes of goats were observed continuously, and the brain tissue was taken at the corresponding time points. The contents of 5-hydroxytryptamine 5-hydroxyindoleacetic acid (5-hydroxyindoleacetic acid) (NEA) and dopamine (DAA) were determined by high performance liquid chromatography (HPLC). The results showed that midazolam mainly acted on the brain and brain stem. The contents of 5-HT and 5-HIAA increased and the contents of NE and DA decreased.
【作者單位】： 東北農業(yè)大學動物醫(yī)學學院;內蒙古扎魯特旗農牧業(yè)局北鎮(zhèn)獸醫(yī)院;
【基金】：黑龍江省教育廳項目(12531016)
【分類號】：S859.7

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1 劉子睿;咪達唑侖對離體胎鼠神經細胞的影響研究[D];東北農業(yè)大學;2014年

2 張思學;賽拉嗪復合麻醉劑對山羊中樞單胺類神經遞質的影響[D];東北農業(yè)大學;2012年

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