Polylactide（PLA） microspheres were prepared using the solid-in-oil（S/O） spray-drying method to achieve the sustained release of a hydrophilic drug for the treatment of tuberculosis, via intratracheal instillation. Isoniazid（IN）, a low-molecular-weight hydrophilic drug, was used as a model drug. The effects of various sizes of micronized IN powder, different drug/polymer ratios, spray-drying process parameters, and drug-release characteristics were studied to optimize the manufacturing parameters... 

【文章來源】：Science China（Life Sciences）. 2016,59(07)SCICSCD

【文章頁數(shù)】：8 頁

【部分圖文】：

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本文編號：3489125