【摘要】：目的:是通過檢測丙肝病毒感染者外周血維生素D的水平,來初步探討其與細(xì)胞免疫變化的關(guān)系及其臨床意義。方法:是采用電化學(xué)發(fā)光法測定丙肝病毒感染者外周血25-羥基維生素D水平,同時用流式細(xì)胞儀檢測CD4+和CD8+T細(xì)胞、NK細(xì)胞的細(xì)胞數(shù),并計算CD4+T細(xì)胞/CD8+T細(xì)胞比值。結(jié)果:丙肝病毒感染者外周血維生素D與細(xì)胞免疫變化有一定關(guān)系,細(xì)胞免疫較正常健康志愿者對照組比較水平降低,差異均有統(tǒng)計學(xué)意義。結(jié)論:是丙肝病毒感染者外周血維生素D和細(xì)胞免疫平均水平較正常人群低,維生素D不足程度越高的HCV感染人群其細(xì)胞免疫較正常人群降低越明顯。
[Abstract]:Objective: to explore the relationship between vitamin D and cellular immunity and its clinical significance by detecting the level of vitamin D in peripheral blood of hepatitis C virus infected patients. Methods: the levels of 25-hydroxyvitamin D in peripheral blood of patients infected with hepatitis C virus were measured by electrochemiluminescence, and the number of CD4, CD8 T cells and NK cells were measured by flow cytometry, and the ratio of CD4 T cells to CD8 T cells was calculated. Results: the level of vitamin D in peripheral blood of patients with hepatitis C virus infection was lower than that of healthy volunteers, and the level of cellular immunity was significantly lower than that of healthy volunteers. Conclusion: the average levels of vitamin D and cellular immunity in peripheral blood of patients with hepatitis C virus infection are lower than those of normal subjects. The higher the level of vitamin D deficiency, the lower the cellular immunity of HCV infected people.
【作者單位】： 廣東省東莞市人民醫(yī)院檢驗科;
【基金】：東莞市醫(yī)療衛(wèi)生單位科技計劃一般項目(編號:201410515000062)
【分類號】：R512.63;R446.6

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本文編號：2373164