發(fā)布時(shí)間：2018-11-24 20:49

【摘要】：目的探討HIV感染者和AIDS患者外周血T淋巴細(xì)胞活化亞群與病毒載量相關(guān)性。方法 2012年6-8月選擇河南省某AIDS高發(fā)地區(qū)HIV感染者322例和AIDS患者87例為研究對(duì)象,分別采用流式細(xì)胞儀和全自動(dòng)病毒載量?jī)x檢測(cè)HIV感染者和AIDS患者外周血T淋巴細(xì)胞及其活化亞群和血漿病毒載量,根據(jù)病毒載量水平將研究對(duì)象分為Ⅰ-Ⅳ組。結(jié)果HIV感染者與AIDS患者CD_3~+T細(xì)胞相對(duì)值、CD_(28)~+/CD_4~+比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。HIV感染者淋巴細(xì)胞絕對(duì)值和相對(duì)值、CD_3~+T細(xì)胞絕對(duì)值、CD_3~+CD_8~+T細(xì)胞絕對(duì)值、CD_3~+CD_4~+T細(xì)胞絕對(duì)值和相對(duì)值、CD_3~+CD_4~+CD_8~+T細(xì)胞絕對(duì)值均高于AIDS患者,CD_3~+CD_8~+T細(xì)胞相對(duì)值低于AIDS患者,輔助性T細(xì)胞與抑制性T細(xì)胞比值(H/S)、CD_(28)~+/CD_8~+高于AIDS患者,CD_(38)~+/CD_8~+低于AIDS患者,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。各組淋巴細(xì)胞絕對(duì)值和相對(duì)值、CD_3~+T細(xì)胞相對(duì)值、CD_3~+CD_8~+T細(xì)胞相對(duì)值、CD_3~+CD_4~+T細(xì)胞絕對(duì)值和相對(duì)值及H/S、CD_(28)~+/CD_4~+、CD_(28)~+/CD_8~+、CD_(38)~+/CD_8~+比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。CD_3~+T細(xì)胞相對(duì)值、CD_3~+CD_8~+T細(xì)胞相對(duì)值及CD_(38)~+/CD_8~+與病毒載量水平呈正相關(guān)(r_s=0.128、0.291、0.409,P0.05);CD_3~+CD_4~+T細(xì)胞絕對(duì)值和相對(duì)值、H/S、CD_(28)~+/CD_4~+、CD_(28)~+/CD_8~+與病毒載量水平呈負(fù)相關(guān)(r_s=-0.246、-0.318、-0.297、-0.184、-0.204,P0.05)。結(jié)論 HIV感染者和AIDS患者T淋巴細(xì)胞活化過程發(fā)生變化;隨著病毒載量水平變化,HIV感染者和AIDS患者的T淋巴細(xì)胞活化亞群水平也不同。
[Abstract]:Objective to investigate the correlation between T lymphocyte activation subsets and viral load in HIV infected patients and AIDS patients. Methods 322 cases of HIV infection and 87 cases of AIDS in a high incidence area of AIDS in Henan Province were selected from June to August 2012. The peripheral blood T lymphocytes and their activated subsets and plasma viral load of HIV infected patients and AIDS patients were detected by flow cytometry and automatic virus loading instrument, respectively. According to the viral load level, the subjects were divided into group 鈪，

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