本文選題：T細胞CCR基因 + megaTAL��； 參考：《中國病理生理雜志》2017年02期

【摘要】：正已有研究表明,HIV-1協(xié)同受體(co-receptor)CCR5基因中自然發(fā)生的32個堿基對缺失(32-base pair deletion)可保護人CD4~+T細胞,對抗HIV感染。最近用工程化核酸酶干擾該基因和模擬此突變的基因工程方法展示了HIV治療獲得成功的跡象。Romano Ibarra等研制了一個靶向CCR5基因第3細胞外莖環(huán)(extracellular loop)的megaTAL核酸酶,并通過mRNA轉(zhuǎn)染
[Abstract]:It has been shown that 32 base pair deletion (32-base pair deletion) in the co-receptor CCR5 gene of HIV-1 can protect human CD4T cells against HIV infection.Recently, a megaTAL nuclease targeting the extracellular loop of the third cell of CCR5 gene was developed by using engineering nuclease to interfere with the gene and the genetic engineering method to simulate the mutation. Romano Ibarra and others developed a megaTAL nuclease targeted at the third cell of CCR5 gene, which was transfected by mRNA.
【分類號】：R512.91
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本文編號：1749709