本文關(guān)鍵詞： 血吸蟲(chóng)病 吡喹酮 纖維化　出處：《中國(guó)血吸蟲(chóng)病防治雜志》2017年02期 　論文類(lèi)型：期刊論文

【摘要】：目的觀察多次吡喹酮治療對(duì)抗血吸蟲(chóng)病肝纖維化的作用。方法選擇60例血吸蟲(chóng)病肝纖維化患者(臨床診斷病例),隨機(jī)分成治療組和對(duì)照組,每組30人。治療組在常規(guī)護(hù)肝、對(duì)癥治療的基礎(chǔ)上連續(xù)3年每年給予吡喹酮60 mg/kg,分2 d服完;對(duì)照組予以常規(guī)的護(hù)肝、對(duì)癥治療,2組療程均為36個(gè)月。觀察治療前后2組患者臨床癥狀、肝功能及血清透明質(zhì)酸(HA)、層粘蛋白(LN)、4型膠原(IV-C)、Ⅲ型前膠原肽(PCIII)等肝纖維化指標(biāo)的變化,并作統(tǒng)計(jì)分析。結(jié)果治療組患者臨床癥狀、肝功能及HA、LN、IV-C、PCIII水平均有不同程度下降,總有效率93%(26/28),對(duì)照組總有效率60%(16/27),兩組差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論多次吡喹酮治療對(duì)抗血吸蟲(chóng)病肝纖維化有較好的治療效果。
[Abstract]:Objective to observe the protective effect of praziquantel on hepatic fibrosis of schistosomiasis. Methods 60 patients with hepatic fibrosis of schistosomiasis were randomly divided into treatment group (n = 30) and control group (n = 30). On the basis of symptomatic treatment, 60 mg / kg praziquantel was administered every year for 3 consecutive years, and the control group was given routine liver protection and the course of treatment was 36 months. The clinical symptoms of the two groups were observed before and after treatment. The changes of liver function and serum hyaluronic acid HAI, laminin LNN 4 collagen type IV-CN, type 鈪，

本文編號(hào)：1526445