本文關(guān)鍵詞： 脊髓灰質(zhì)炎實(shí)驗(yàn)室網(wǎng)絡(luò) 脊髓灰質(zhì)炎病毒 疫苗衍生脊髓灰質(zhì)炎病毒　出處：《中國(guó)疫苗和免疫》2017年02期 　論文類型：期刊論文

【摘要】：目的評(píng)價(jià)中國(guó)(未包括香港、澳門(mén)特別行政區(qū)和臺(tái)灣地區(qū))2015年脊髓灰質(zhì)炎(脊灰)實(shí)驗(yàn)室網(wǎng)絡(luò)(Polio laboratory network,PLN)運(yùn)轉(zhuǎn)情況,為中國(guó)維持無(wú)脊灰狀態(tài)提供病毒學(xué)依據(jù)。方法對(duì)中國(guó)急性弛緩性麻痹(Acute flaccid paralysis,AFP)病例監(jiān)測(cè)信息報(bào)告管理系統(tǒng)中31個(gè)省(自治區(qū)、直轄市)報(bào)告的AFP病例和中國(guó)疾病預(yù)防控制中心(CDC)病毒病預(yù)防控制所國(guó)家脊灰實(shí)驗(yàn)室(National Polio Laboratory,NPL)的監(jiān)測(cè)數(shù)據(jù)庫(kù)進(jìn)行統(tǒng)計(jì)分析,對(duì)PLN的各項(xiàng)運(yùn)轉(zhuǎn)指標(biāo)進(jìn)行評(píng)價(jià)。結(jié)果 2015年中國(guó)共報(bào)告5 218例AFP病例,PLN收到5 173例AFP病例的10 335份糞便標(biāo)本;14天內(nèi)雙份糞便標(biāo)本采集率為92.76%;合格糞便標(biāo)本采集率為92.16%,病毒分離結(jié)果 14天內(nèi)反饋率為96%。5 173例病例中,L20B陽(yáng)性69例(1.33%);非脊灰腸道病毒(Non-polio enterovirus,NPEV)陽(yáng)性472例(9.12%)。NPL收到省級(jí)脊灰實(shí)驗(yàn)室送檢的分離自AFP病例、非AFP病例、AFP病例接觸者及健康人的179株L20B細(xì)胞陽(yáng)性分離物,其中173株為脊灰病毒(Poliovirus,PV),4株為NPEV,2株為非腸道病毒(Non-enterovirus,NEV)。173株P(guān)V中,8株為疫苗衍生脊灰病毒(Vaccine-derived poliovirus,VDPV),來(lái)自浙江、廣東和遼寧;未發(fā)現(xiàn)脊灰野病毒(Wild poliovirus,WPV)。從脊灰病毒外環(huán)境監(jiān)測(cè)采集的污水標(biāo)本中分離到1株Ⅱ型VDPV。2015年NPL和31個(gè)省CDC脊灰實(shí)驗(yàn)室都通過(guò)了世界衛(wèi)生組織(WHO)糞便標(biāo)本脊灰等腸道病毒的新檢測(cè)流程的能力驗(yàn)證標(biāo)本考核。NPL和27個(gè)省CDC脊灰實(shí)驗(yàn)室通過(guò)了WHO型內(nèi)鑒定能力驗(yàn)證考核。結(jié)論中國(guó)PLN 2015年運(yùn)轉(zhuǎn)正常,未發(fā)現(xiàn)WPV,為維持中國(guó)無(wú)脊灰狀態(tài),早期發(fā)現(xiàn)VDPV或VDPV病例,早期采取應(yīng)對(duì)措施阻斷其傳播提供了重要的病毒學(xué)依據(jù)。
[Abstract]:Objective to evaluate the operation of Polio laboratory Network in 2015 in China (excluding Hong Kong, Macao Special Administrative region and Taiwan). Methods 31 provinces (autonomous regions) of acute flaccid paralysis (AFP) case monitoring information management system in China were used to provide virological basis for maintaining poliomyelitis free status. The surveillance database of AFP cases reported by the municipality directly under the Central Government and the National Polio Laboratory of the National Institute for Polio Disease Control and Prevention of the China Centers for Disease Control and Prevention (CDC) was statistically analyzed. Results in 2015, 5 218 cases of AFP were reported to have received 10 335 fecal specimens from 5 173 cases of AFP in China. The collection rate of double stool specimens in 14 days was 92.766.The rate of collection of qualified stool specimens was 92.76. For 92.16, the feedback rate in 14 days was 96.5 173 cases, 69 cases were positive for L20B, 472 cases were positive for non-poliomyelitis enterovirus.NPL received AFP cases from provincial polio laboratory. There are 179 strains of L20B cell positive isolates from non-AFP case contacts and healthy people, of which 173 strains are Poliovirusus PVV, 4 strains are NPEV virus, 2 strains are non-enterovirus.173 strains PV, 8 strains are vaccine-derived poliovirus vaccine-derived poliovirus virion, from Zhejiang, Guangdong and Liaoning. Wild poliovirus wild poliovirus was not found. One strain of NPL of type II VDPV.2015 year and 31 provincial CDC polio laboratories were isolated from waste water samples collected from external environment monitoring of poliovirus. All of them passed World Health Organization (WHO) fecal specimen polio and other enterovirus. NPL and 27 provincial CDC poliomyelitis laboratories passed the WHO type test. Conclusion in 2015, PLN in China operated normally. The absence of WPVprovides an important virological basis for maintaining poliomyelitis in China, early detection of VDPV or VDPV cases, and early response measures to block the transmission of WPVs.
【作者單位】： 中國(guó)疾病預(yù)防控制中心病毒病預(yù)防控制所國(guó)家衛(wèi)生和計(jì)劃生育委員會(huì)醫(yī)學(xué)病毒學(xué)和病毒病重點(diǎn)實(shí)驗(yàn)室世界衛(wèi)生組織西太平洋區(qū)脊髓灰質(zhì)炎參比實(shí)驗(yàn)室;浙江省疾病預(yù)防控制中心;中國(guó)疾病預(yù)防控制中心免疫規(guī)劃中心;
【基金】：行使WHO西太區(qū)脊灰參比實(shí)驗(yàn)室職能,2015年國(guó)家衛(wèi)生和計(jì)劃生育委員會(huì)疾病控制專項(xiàng)
【分類號(hào)】：R512.4

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