本文關鍵詞： 中性粒細胞CD 乙肝肝硬化 自發(fā)性細菌性腹膜炎 抗生素　出處：《中國現(xiàn)代醫(yī)學雜志》2017年19期 　論文類型：期刊論文

【摘要】：目的探討中性粒細胞CD64對乙肝肝硬化并發(fā)自發(fā)性細菌性腹膜炎(SBP)應用抗生素的指導價值。方法將134例乙肝肝硬化并發(fā)SBP患者隨機分為CD64組(73例)和對照組(61例),CD64組根據(jù)中性粒細胞CD64作為開始和停用抗生素的依據(jù);對照組按照常規(guī)方法應用抗生素。比較兩組患者的抗生素療程、抗生素費用、住院時間、住院費用、Child-Pugh評分、MELD評分、臨床有效率及病死率。結果 CD64組抗生素療程8 d(6~14 d)、抗生素費用781元(458~4 297元)、住院時間15 d(6~29 d)、住院費用7 328元(4 951~13 916元)均低于對照組分別為11 d(7~20 d),1 084元(728~5 822元),20 d(10~35 d),10 239元(5 325~19 824元)。治療結束后CD64組與對照組患者Child-pugh評分[(9.26±3.24)vs(9.72±3.12)]、MELD評分[(16.16±8.04)vs(15.71±8.13)]、臨床有效率(90.41%vs 91.80%)和病死率(4.11%vs 3.28%)比較,均差異無統(tǒng)計學意義(均P0.05)。結論中性粒細胞CD64可作為乙肝肝硬化并發(fā)SBP患者臨床抗生素應用的參考指標,并能夠縮短抗生素使用時間和住院天數(shù)。
[Abstract]:Objective to investigate the value of neutrophil CD64 in the application of antibiotics in patients with hepatitis B cirrhosis complicated with spontaneous bacterial peritonitis. Methods 134 patients with hepatitis B cirrhosis complicated with SBP were randomly divided into CD64 group (n = 73) and control group (n = 61). Neutrophil CD64 was used as the basis for the initiation and discontinuation of antibiotics. The patients in the control group were treated with antibiotics according to the routine method. The course of antibiotic treatment, the cost of antibiotics, the length of hospitalization, the Child-Pugh score and meld score were compared between the two groups. Results the clinical effective rate and mortality rate in CD64 group were lower than those in control group (11 days, 720 days, 1084 days, 781 yuan, 458min, 4297 yuan, 15 days, 629 days, 7 328 yuan / 4 951U 13 916), respectively, which were lower than those in the control group (11 days, 720 days, 1 084 days, 728 yuan, 5 822 yuan), respectively, in the CD64 group, the course of antibiotic treatment was 8 days, the course of treatment was 6 days, the cost of antibiotics was 781 yuan, the cost of antibiotics was 4 297 yuan. After treatment, the Child-pugh score of CD64 group and control group [9.26 鹵3.24 vs 9.72 鹵3.12)] meld score [16.16 鹵8.04 vs 15.71 鹵8.13], the clinical effective rate was 90.41 vs 91.80) and the mortality was 4.11m vs 3.28). Conclusion neutrophil CD64 can be used as a reference index for the clinical use of antibiotics in patients with hepatitis B cirrhosis complicated with SBP, and can shorten the duration of antibiotic use and hospital stay.
【作者單位】： 福建醫(yī)科大學孟超肝膽醫(yī)院(福州市傳染病醫(yī)院);
【基金】：福州市衛(wèi)生系統(tǒng)科技計劃項目(No:2016-S-wq7)
【分類號】：R512.62;R572.2;R575.2
，

本文編號：1498710