發(fā)布時(shí)間：2018-01-17 21:25

  本文關(guān)鍵詞：免疫阻斷乙型肝炎病毒母嬰傳播多中心研究　出處：《中國(guó)實(shí)用婦科與產(chǎn)科雜志》2015年01期 　論文類型：期刊論文

  更多相關(guān)文章： 乙型肝炎病毒 孕產(chǎn)婦 乙型肝炎免疫球蛋白 母嬰傳播 免疫阻斷

【摘要】：目的探討孕產(chǎn)婦乙型肝炎表面抗原(HBs Ag)陽(yáng)性率及乙型肝炎病毒(HBV)母嬰傳播阻斷的效果。方法2008-2012年,通過(guò)多中心隊(duì)列研究,對(duì)湖北省、山西省、廣東省、新疆維吾爾自治區(qū)等地的孕產(chǎn)婦進(jìn)行HBs Ag篩查;對(duì)上述地區(qū)部分醫(yī)院入院分娩的HBs Ag陽(yáng)性母親及8~12個(gè)月齡嬰兒進(jìn)行隨訪觀察,所有標(biāo)本檢測(cè)乙型肝炎血清標(biāo)志物(HBs Ag,HBs Ab,HBe Ag,HBe Ab,HBc Ab),部分標(biāo)本檢測(cè)HBV DNA。結(jié)果篩查孕婦82214例,HBs Ag陽(yáng)性4924例,陽(yáng)性率6.0%。隨訪HBs Ag陽(yáng)性母親及8~12個(gè)月齡嬰兒1371對(duì),嬰兒免疫阻斷失敗率3.1%(42/1371),HBs Ag及HBe Ag雙陽(yáng)性母親嬰兒的免疫阻斷失敗率為8.2%。免疫阻斷失敗的嬰兒其母親均為HBe Ag陽(yáng)性且HBV DNA≥6 log10copies/m L。HBe Ag陽(yáng)性母親孕期注射乙型肝炎免疫球蛋白(hepatitis B immune globulin,HBIG)及未注射HBIG組,其嬰兒免疫阻斷失敗率差異無(wú)統(tǒng)計(jì)學(xué)意義(8.8%vs.8.1%,P=0.807)。結(jié)論多中心調(diào)查顯示目前孕產(chǎn)婦HBs Ag陽(yáng)性率6.0%,HBV母嬰阻斷失敗率3.1%。HBs Ag及HBe Ag雙陽(yáng)性且HBV DNA≥6 log10 copies/m L的孕婦應(yīng)為母嬰阻斷的重點(diǎn)人群。孕婦孕期注射HBIG不能提高HBV母嬰阻斷效果。
[Abstract]:Objective to investigate the positive rate of hepatitis B surface antigen (HBs) and the effect of blocking mother-to-child transmission of hepatitis B virus (HBV) in pregnant women. HBs Ag screening was performed on pregnant women in Hubei Province, Shanxi Province, Guangdong Province and Xinjiang Uygur Autonomous region through multicenter cohort study. HBs Ag positive mothers and infants aged from 8 to 12 months were followed up in some hospitals. All samples were tested for HBs Ag in serum. Results 82214 pregnant women were screened for HBs Ag positive for 4 924 cases. The positive rate was 6.0%. 1 371 pairs of infants aged 8 to 12 months were followed up with HBs Ag positive mothers. The failure rate of immune blockade was 3.1% (42 / 1371). The failure rate of HBs Ag and HBe Ag double positive mothers was 8.2%. The mothers of the infants who failed the immune block were both HBe Ag positive and HBV DNA 鈮，

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