【摘要】： 心率變異性分析作為一種無(wú)創(chuàng)性檢查自主神經(jīng)系統(tǒng)功能的方法,目前已經(jīng)被應(yīng)用于臨床。如:心血管系統(tǒng)疾病、糖尿病病情進(jìn)展和愈后的評(píng)估以及麻醉深度的監(jiān)測(cè)等等。然而在研究過(guò)程中,HRV頻譜分析中某些成分生理學(xué)意義尚未明確, HRV在探索疾病中自主神經(jīng)系統(tǒng)改變的作用如在自發(fā)性高血壓中的作用等等仍需進(jìn)一步的研究。這些研究許多數(shù)情況下需要基礎(chǔ)研究工作人員應(yīng)用動(dòng)物模型進(jìn)行長(zhǎng)期的觀察和探討。因此,對(duì)實(shí)驗(yàn)動(dòng)物心電信號(hào)的記錄及心率變異分析系統(tǒng)十分必要。目前存在的心電信號(hào)的自動(dòng)分析系統(tǒng)市場(chǎng)價(jià)格多較高,而且多用于臨床研究。本實(shí)驗(yàn)設(shè)計(jì)以WINDOWS操作系統(tǒng)為平臺(tái)、應(yīng)用C語(yǔ)言研制開(kāi)發(fā)一種應(yīng)用于對(duì)動(dòng)物心電信號(hào)中包含的心率變異信息的實(shí)時(shí)提取及分析系統(tǒng)。以利于對(duì)今后開(kāi)展的HRV分析研究工作提供準(zhǔn)確的分析工具。并通過(guò)動(dòng)物實(shí)驗(yàn)對(duì)該程序進(jìn)行測(cè)試。本系統(tǒng)主要包括心電信號(hào)實(shí)時(shí)的采集模塊、心電信號(hào)保存模塊,HRV時(shí)域分析模塊(RR間期提取、RR間期直方圖、RR間期統(tǒng)計(jì)學(xué)分析),RR間期的Lorenz圖。頻域分析模塊(HRV的功率譜分析),并且通過(guò)對(duì)Wistar心肌缺血大鼠傾斜實(shí)驗(yàn)前后心電信號(hào)的記錄進(jìn)行心率變異性分析。經(jīng)測(cè)試,此系統(tǒng)完全可以滿足目前基礎(chǔ)實(shí)驗(yàn)中實(shí)驗(yàn)動(dòng)物的心電信號(hào)的提取及心率變異性分析的需要。
[Abstract]:Heart rate variability analysis (HRV), as a non-invasive method to examine autonomic nervous system function, has been used in clinical practice. For example: cardiovascular disease, diabetes progression and recovery assessment, as well as anesthesia depth monitoring and so on. However, the physiological significance of some components in HRV spectrum analysis is not clear. The role of HRV in exploring the changes of autonomic nervous system in diseases, such as the role in spontaneous hypertension and so on, needs to be further studied. Many of these studies require long-term observation and discussion by basic researchers using animal models. Therefore, it is necessary to record ECG signals and analyze heart rate variability in experimental animals. At present, the market price of ECG automatic analysis system is high, and most of them are used in clinical research. In this experiment, a real-time extraction and analysis system for heart rate variability contained in animal ECG signals was developed by using C language on the platform of WINDOWS operating system. In order to provide accurate analytical tools for the future work of HRV analysis. The program was tested by animal experiment. The system mainly includes ECG real-time acquisition module, ECG signal storage module, HRV time domain analysis module (RR interval extraction, RR interval histogram, RR interval statistical analysis of), RR interval Lorenz map). Frequency domain analysis module (HRV power spectrum analysis) and heart rate variability (HRV) were analyzed by recording ECG signals before and after tilting test in Wistar myocardial ischemia rats. The test results show that the system can fully meet the needs of ECG signal extraction and heart rate variability analysis of experimental animals in basic experiments.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2006
【分類號(hào)】：R-331

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