溶藻弧菌抗獨特型抗體基因工程疫苗的研究
發(fā)布時間：2018-10-21 13:55
【摘要】：魚病已成為水產養(yǎng)殖業(yè)發(fā)展的主要障礙,制約著水產養(yǎng)殖業(yè)的發(fā)展。魚病的現(xiàn)有防治方法多使用各種化學藥物、抗生素和減毒、滅活疫苗�？股氐拈L期使用易使魚類產生耐藥性,而且抗生素的殘留會通過食物鏈對人類造成危害。而現(xiàn)有的傳統(tǒng)疫苗的安全性難以掌握。滅活疫苗由于使用物理、化學的方法滅活,在制備過程中抗原活性有可能受到破壞,并且殘留的細菌內毒素及其它雜質可能會使魚體出現(xiàn)炎癥而死亡。減毒疫苗保留的部分毒性會影響周圍環(huán)境的生物。國內外水產科技工作者正積極尋求防治效果好,安全性高,不產生抗藥性,無藥物殘留,而且不會造成環(huán)境污染的防治魚病方法。 國外已有新型疫苗出現(xiàn),如核酸疫苗,合成肽疫苗及抗獨特型抗體疫苗等,但這些新型疫苗在安全性、廉價性等方面各有優(yōu)勢也各有缺陷,由于各種原因目前還停留在實驗室階段而未能大量用于養(yǎng)殖漁業(yè)。目前對于抗獨特型抗體疫苗作為新一代疫苗日益受到重視。針對
[Abstract]:Fish disease has become a major obstacle to the development of aquaculture, restricting the development of aquaculture. The existing prevention and cure methods of fish disease mostly use all kinds of chemical drugs, antibiotics and attenuated, inactivated vaccine. Long-term use of antibiotics makes fish resistant, and antibiotic residues can harm humans through the food chain. The safety of existing traditional vaccines is difficult to grasp. Due to the inactivation of the inactivated vaccine by physical and chemical methods, the antigen activity may be destroyed during the preparation process, and the residual bacterial endotoxin and other impurities may cause inflammation and death in the fish body. Some of the toxicity retained by attenuated vaccines can affect the surrounding organisms. Aquatic science and technology workers at home and abroad are actively seeking to control fish disease with good control effect, high safety, no drug resistance, no drug residue, and no environmental pollution. There have been new vaccines abroad, such as nucleic acid vaccine, synthetic peptide vaccine and anti-idiotypic antibody vaccine. However, these new vaccines have their own advantages and disadvantages in terms of safety, low cost, etc. For various reasons, it is still in the laboratory stage and can not be used in aquaculture fishery. At present, more and more attention has been paid to anti-idiotypic antibody vaccine as a new generation vaccine. In response to
【學位授予單位】：第四軍醫(yī)大學
【學位級別】：博士
【學位授予年份】：2005
【分類號】：R392
本文編號：2285279
[Abstract]:Fish disease has become a major obstacle to the development of aquaculture, restricting the development of aquaculture. The existing prevention and cure methods of fish disease mostly use all kinds of chemical drugs, antibiotics and attenuated, inactivated vaccine. Long-term use of antibiotics makes fish resistant, and antibiotic residues can harm humans through the food chain. The safety of existing traditional vaccines is difficult to grasp. Due to the inactivation of the inactivated vaccine by physical and chemical methods, the antigen activity may be destroyed during the preparation process, and the residual bacterial endotoxin and other impurities may cause inflammation and death in the fish body. Some of the toxicity retained by attenuated vaccines can affect the surrounding organisms. Aquatic science and technology workers at home and abroad are actively seeking to control fish disease with good control effect, high safety, no drug resistance, no drug residue, and no environmental pollution. There have been new vaccines abroad, such as nucleic acid vaccine, synthetic peptide vaccine and anti-idiotypic antibody vaccine. However, these new vaccines have their own advantages and disadvantages in terms of safety, low cost, etc. For various reasons, it is still in the laboratory stage and can not be used in aquaculture fishery. At present, more and more attention has been paid to anti-idiotypic antibody vaccine as a new generation vaccine. In response to
【學位授予單位】：第四軍醫(yī)大學
【學位級別】：博士
【學位授予年份】：2005
【分類號】：R392
【引證文獻】
相關期刊論文 前1條
1 李淑娜;蔣文燦;鄭維維;劉義鈴;;抗獨特型疫苗在獸醫(yī)領域的研究進展[J];動物醫(yī)學進展;2008年02期
，本文編號：2285279
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