發(fā)布時(shí)間：2018-08-11 09:33

【摘要】：運(yùn)動(dòng)前神經(jīng)元在運(yùn)動(dòng)的產(chǎn)生、維持機(jī)體運(yùn)動(dòng)的協(xié)調(diào)等方面具有重要作用。既往的研究已經(jīng)證實(shí)運(yùn)動(dòng)前神經(jīng)元參與反射性活動(dòng)局部神經(jīng)環(huán)路的構(gòu)成。傷害性反射(nociceptive reflexes,NR)是機(jī)體最基本的保護(hù)性反射,是研究傷害性信息在中樞內(nèi)傳遞、中樞敏化、痛敏、觸痛及牽涉痛等機(jī)制的極為理想的模型。中樞神經(jīng)系統(tǒng)某些疾病,如血腫、腫瘤或梗死等都可由于其破壞了反射弧的完整性,進(jìn)而引起反射功能障礙或紊亂。因此,NR也可為臨床上判斷中樞神經(jīng)系統(tǒng)病變的部位提供形態(tài)學(xué)依據(jù)。迄今為止,關(guān)于NR局部環(huán)路的研究多集中在脊髓水平,如傷害性屈肌反射(nociceptive flexion reflex,NFR),但對(duì)于口面部反射,如頜反射(Jaw reflex,JR),角膜反射(corneal reflex,CR),尤其是對(duì)該局部環(huán)路上運(yùn)動(dòng)前神經(jīng)元的研究則由于傳遞口面部感覺(jué)信息的三叉神經(jīng)系統(tǒng)以及支配口面部肌肉運(yùn)動(dòng)的核團(tuán)結(jié)構(gòu)和功能的復(fù)雜性而鮮見(jiàn)報(bào)道。鑒于此,本論文綜合應(yīng)用多種形態(tài)學(xué)方法系統(tǒng)研究了參與口面部傷害性信息傳遞的運(yùn)動(dòng)前神經(jīng)元在腦干內(nèi)的分布情況和分支投射,以及這些運(yùn)動(dòng)前神經(jīng)元及其所接受的來(lái)自三叉神經(jīng)脊束核尾側(cè)亞核(caudal spinal trigeminal nucleus,Vc)投射神經(jīng)元的軸突終末所含有的化學(xué)神經(jīng)遞質(zhì)。本論文包括以下三個(gè)方面的內(nèi)容: 1.參與大鼠口面部傷害性反射局部環(huán)路的運(yùn)動(dòng)前神經(jīng)元在腦干內(nèi)的分布 應(yīng)用順行、逆行束路追蹤的方法,將逆行追蹤劑[熒光金(Fluoro-Gold,FG)或辣根過(guò)氧化物酶(horseradish peroxide,HRP)]
[Abstract]:Pre-motor neurons play an important role in the generation of motor and the maintenance of motor coordination. Previous studies have confirmed that premotor neurons are involved in the formation of local neural loops of reflex activity. Nociceptive reflexesus NR is the most basic protective reflex in the body. It is an ideal model for studying the mechanism of nociceptive information transmission, central sensitization, pain sensitivity, tenderness and involved pain in the central nervous system. Some diseases of the central nervous system, such as hematoma, tumor or infarction, can destroy the integrity of reflex arc and cause reflex dysfunction or disorder. Therefore, NR can also provide morphological basis for clinical diagnosis of central nervous system lesions. Up to now, most studies on NR local loop have focused on spinal cord level, such as (nociceptive flexion reflexNFR, but for oral and facial reflex, For example, Jaw reflexus JR, corneal reflex CR, especially the study of premotor neurons in the local loop, due to the structure and function of trigeminal nerve system which conveys the facial sensory information and innervates the movement of the facial muscles of the mouth. Complexity is rarely reported. In view of this, the distribution and branching projections of premotor neurons involved in oral and facial nociceptive information transmission in the brain stem were systematically studied by various morphological methods. And the chemical neurotransmitters contained in these premotor neurons and the axon terminals of the (caudal spinal trigeminal nucleus VC projecting neurons from the caudal subnucleus of the spinal trigeminal nucleus. This thesis includes the following three aspects: 1. The distribution of premotor neurons involved in the local loop of oral and facial nociceptive reflex in the rat brain stem was followed by anterograde and retrograde traceability. Retrograde tracing agent [Fluoro-Goldin FG or horseradish peroxidase]
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類號(hào)】：R329

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