本文選題：天然免疫 + 呼吸道上皮細(xì)胞��； 參考：《四川大學(xué)》2006年碩士論文

【摘要】：天然免疫系統(tǒng)近年來頗受關(guān)注，它是生物體賴以生存的最基本條件，是抵御微生物入侵的第一道屏障，是生物體在長期種系發(fā)生和進(jìn)化過程中逐漸形成的，對各種病原微生物都具有抗感染的作用。與獲得性免疫系統(tǒng)一起組成了人體抵御外界的兩大重要防御機制。 天然免疫識別的是微生物生存所必需的，相對保守的，并且宿主不具備的病原體相關(guān)模式分子(pathogen-associated molecular patterns，PAMP)，包括革蘭陰性菌的脂多糖(LPS)、革蘭陽性菌的磷壁酸、病毒的雙鏈RNA、細(xì)菌的非甲基化CpGDNA、細(xì)菌的蛋白特征分子甲酰甲硫氨酰肽等。而天然免疫系統(tǒng)的受體則稱為模式分子識別受體(pattern recognition receptors，PRRs)。識別受體是在種系發(fā)生中產(chǎn)生，是長期自然選擇的結(jié)果。目前研究較多的兩種主要的受體分別為Toll受體與Nods蛋白受體。經(jīng)研究表明Nods蛋白受體，主要是Nod1和Nod2，分布在腸道等上皮細(xì)胞胞漿中，，能識別細(xì)菌胞壁肽聚糖成分，能被細(xì)胞因子及侵襲性細(xì)菌上調(diào)表達(dá)，激活NF-κB信號途徑，啟動機體的免疫應(yīng)答和炎癥反應(yīng)。 本項研究的目的是檢測呼吸道上皮細(xì)胞和膀胱上皮細(xì)胞中有無Nod2的表達(dá)，并進(jìn)一步探討其表達(dá)的調(diào)控因素以及其胞內(nèi)信號轉(zhuǎn)導(dǎo)通路。
[Abstract]:The innate immune system has attracted much attention in recent years. It is the most basic condition for the survival of organisms, the first barrier against the invasion of microorganisms, and the gradual formation of organisms in the course of long-term phylogeny and evolution. It has anti-infection effect to various pathogenic microorganisms. Together with the acquired immune system, the body has two important defense mechanisms against the outside world. Innate immunity recognizes pathogen-associated molecular patterns associated with PAMP, which are necessary for microbial survival and are not available to the host, including lipopolysaccharide (LPS) of gram-negative bacteria, and phosphoric acid from gram-positive bacteria. Double stranded RNAs of viruses, demethylated CpGDNAs of bacteria, protein characteristic molecules of bacteria, formylmethionine peptide, etc. The receptors in the innate immune system are called pattern molecule recognition receptors (pattern recognition receptors). Recognition receptors are the result of long-term natural selection. The two main receptors are Toll receptor and Nods protein receptor. The results showed that Nods protein receptors, mainly Nod1 and Nod2, distributed in the cytoplasm of intestinal epithelial cells, recognized peptidoglycan components of bacterial wall, up-regulated expression by cytokines and invasive bacteria, and activated NF- 魏 B signaling pathway. Activate the body's immune response and inflammatory response. The aim of this study was to detect the expression of Nod2 in respiratory epithelial cells and bladder epithelial cells, and to further investigate the regulatory factors and intracellular signal transduction pathways of Nod2 expression.
【學(xué)位授予單位】：四川大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R392

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