本文選題：吞噬細(xì)胞　切入點(diǎn)：凋亡細(xì)胞　出處：《細(xì)胞與分子免疫學(xué)雜志》2014年02期

【摘要】：正常組織新陳代謝中會(huì)產(chǎn)生大量的凋亡細(xì)胞,它們作為機(jī)體自身抗原的主要來(lái)源在誘導(dǎo)免疫耐受中發(fā)揮重要的作用。脾臟邊緣區(qū)的巨噬細(xì)胞(如邊緣區(qū)巨噬細(xì)胞和邊緣區(qū)嗜金屬巨噬細(xì)胞等)和脾臟中的樹(shù)突狀細(xì)胞通過(guò)"find-me"信號(hào)"eatme"信號(hào)快速識(shí)別并清除體內(nèi)不斷產(chǎn)生的凋亡細(xì)胞,以致于在體內(nèi)很難檢測(cè)到凋亡細(xì)胞。同時(shí),凋亡細(xì)胞的清除可誘導(dǎo)機(jī)體對(duì)自身抗原的免疫耐受。并且已有研究指出,清除凋亡細(xì)胞誘導(dǎo)免疫耐受這一理論已被用于預(yù)防自身免疫病和誘導(dǎo)腫瘤免疫。本文主要綜述了機(jī)體清除凋亡細(xì)胞的分子機(jī)制及臨床意義。
[Abstract]:In normal tissue metabolism, a large number of apoptotic cells are produced. They play an important role in inducing immune tolerance as the main source of body autoantigen. Macrophages in the marginal region of the spleen (such as macrophages in the marginal region and metal macrophages in the marginal region) and dendrites in the spleen. The "find-me" signal, "eatme" signal, is used by the cells to quickly recognize and clear the cells that are constantly producing apoptosis in the body. That makes it difficult to detect apoptotic cells in vivo. At the same time, the removal of apoptotic cells can induce the body's immune tolerance to its own antigens. The theory of immune tolerance induced by scavenging apoptotic cells has been used to prevent autoimmune diseases and induce tumor immunity. The molecular mechanism and clinical significance of scavenging apoptotic cells were reviewed in this paper.
【作者單位】： 山東大學(xué)醫(yī)學(xué)院;山東大學(xué)細(xì)胞生物學(xué)研究所;
【基金】：國(guó)家自然科學(xué)基金(81202306) 山東大學(xué)自主創(chuàng)新基金(2011TB013)
【分類號(hào)】：R392

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