本文關(guān)鍵詞：顱內(nèi)動(dòng)脈瘤動(dòng)物模型建立及發(fā)病機(jī)制的研究　出處：《四川大學(xué)》2005年博士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 顱內(nèi)動(dòng)脈瘤 發(fā)病機(jī)制 CD68 c-Jun MMP-9 動(dòng)物模型 改良入路

【摘要】：血管壁細(xì)胞外基質(zhì)的大量破壞是顱內(nèi)動(dòng)脈瘤形成的重要因素,而細(xì)胞外基質(zhì)的破壞與基質(zhì)金屬蛋白酶(matrix metalloproteinase,MMPs)尤其MMP-9過度表達(dá)密切相關(guān),同時(shí)伴有MMP的抑制劑(tissue inhibitor of metalloproteinase,TIMP)表達(dá)升高,但二者的平衡失調(diào)致使MMP-9的超量表達(dá)參與了顱內(nèi)動(dòng)脈瘤的發(fā)生及其發(fā)展。 巨噬細(xì)胞作為重要的炎癥分子通過誘導(dǎo)MMP-9的表達(dá)參與了腹主動(dòng)脈瘤的形成,CD68作為巨噬細(xì)胞的分子標(biāo)志常用于判斷組織內(nèi)炎癥反應(yīng)的程度。此外研究表明MMP-9的過度表達(dá)與轉(zhuǎn)錄因子c-Jun有關(guān),本研究擬探討誘導(dǎo)顱內(nèi)動(dòng)脈瘤血管壁內(nèi)MMP-9的過度表達(dá)相關(guān)調(diào)控機(jī)制,從顱內(nèi)動(dòng)脈瘤MMP-9誘導(dǎo)產(chǎn)生的早期階段阻斷其后繼病理反應(yīng),為臨床開發(fā)新藥或檢測特異性病理分子標(biāo)記物提示顱內(nèi)動(dòng)脈瘤形成早期提供有用的實(shí)驗(yàn)依據(jù)。 自Hashimoto首次運(yùn)用結(jié)扎大鼠一側(cè)頸總動(dòng)脈+切除一側(cè)腎臟+術(shù)后(高鹽飲食+β-丙晴氨)喂養(yǎng)2月等綜合措施成功建立顱內(nèi)動(dòng)脈瘤動(dòng)物模型后,該模型幾經(jīng)改進(jìn)和完善,發(fā)現(xiàn)腎性高血壓和血流動(dòng)力學(xué)異常是制作顱內(nèi)動(dòng)脈瘤發(fā)病機(jī)制模型的兩大基本條件,制作的動(dòng)物模型與人類
[Abstract]:The destruction of a large number of vascular extracellular matrix is an important factor for the formation of intracranial aneurysms, and the destruction of the extracellular matrix and matrix metalloproteinases (matrix, metalloproteinase, MMPs) especially over expression of MMP-9 is closely related with MMP (tissue inhibitor and inhibitor of metalloproteinase, TIMP) expression increased, but the two imbalance resulting in excess the expression of MMP-9 is involved in the occurrence and development of intracranial aneurysm.
As an important form of macrophage inflammatory molecules involved in abdominal aortic aneurysm by inducing the expression of MMP-9, CD68 as a molecular marker of macrophage inflammatory response is used to judge within the organization degree. Furthermore the study showed that the overexpression of MMP-9 related transcription factor c-Jun, this study intends to explore the induce over expression of intracranial aneurysms within the vascular wall of MMP-9 related control mechanism of early stage from MMP-9 intracranial aneurysm induced by blocking its subsequent pathological reaction, for the clinical development of new drugs or detection of specific pathological molecular markers suggest intracranial aneurysm formation to provide experimental basis for useful early.
Since Hashimoto first use of carotid artery ligation in rats after unilateral nephrectomy + + (high salt diet + beta C clear ammonia) comprehensive measures of feeding February successfully established the animal model of intracranial aneurysms after the model has been improved and perfected, found in renal hypertension and abnormal hemodynamics are the two basic conditions of production models of the pathogenesis of intracranial aneurysm, animal models and human production

【學(xué)位授予單位】：四川大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2005
【分類號】：R-332;R739.41

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本文編號：1360670