【摘要】：寨卡病毒系由伊蚊傳播的黃病毒,超過(guò)20億人在其流行區(qū)域生活。近幾年,在中南美洲乃至世界范圍內(nèi)爆發(fā)的寨卡疫情已對(duì)全球公共衛(wèi)生事業(yè)構(gòu)成嚴(yán)重威脅。已有研究證實(shí)寨卡病毒感染為格林巴利綜合征的病因之一;孕婦感染寨卡病毒后,可造成新生兒小頭癥。早日研制出安全有效的寨卡疫苗之重要性不言而喻。全球率先報(bào)道的寨卡疫苗為一款DNA疫苗,其在設(shè)計(jì)、制備和生產(chǎn)方面均較其他類(lèi)型疫苗更加簡(jiǎn)易,且可避免可復(fù)制型疫苗因毒力回復(fù)而造成對(duì)孕婦和胎兒的健康威脅,在寨卡疫苗的研究中具有顯著優(yōu)勢(shì)。其他傳統(tǒng)類(lèi)型疫苗和基于抗體的新型疫苗等均有研究機(jī)構(gòu)開(kāi)展研究,并已取得階段性進(jìn)展,本文將扼要綜述寨卡疫苗的研究現(xiàn)狀與進(jìn)展。
[Abstract]:Zika virus, a yellow virus transmitted by Aedes pipiens, lives in more than 2 billion people in its endemic areas. In recent years, Zika outbreak in Central and South America and throughout the world has posed a serious threat to global public health. Zika virus infection has been identified as one of the causes of Guillain-Barre syndrome; pregnant women infected with Zika virus can cause neonatal microcephaly. The importance of early development of a safe and effective Zika vaccine is self-evident. The Zika vaccine, the first reported vaccine in the world, is an DNA vaccine that is simpler in design, preparation and production than other types of vaccines, and can avoid health threats to pregnant women and fetuses caused by the virulence of replicable vaccines, It has a significant advantage in the study of Zika vaccine. Other traditional vaccines and new vaccines based on antibodies have been studied and some progress has been made. In this paper, the present situation and progress of Zika vaccine are summarized briefly.
【作者單位】： 首都醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院微生物學(xué)與寄生蟲(chóng)學(xué)教研室;北京腦重大疾病研究院癲癇研究所;
【基金】：國(guó)家自然科學(xué)基金(81271839,81372935,81301435,81471957)~~
【分類(lèi)號(hào)】：R392
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本文編號(hào)：2463956